Radiology:这些CT表现,让急性胰腺炎达到“标本兼治”!

2022-01-12 shaosai MedSci原创

急性胰腺炎(AP)是十分常见的炎症性疾病,胆结石是诱发AP的主要因素之一。因此早期识别胆道病变是预防AP至关重要的手段之一,早期的诊断及干预可避免并发症的发生和疾病的复发。

急性胰腺炎(AP)是十分常见的炎症性疾病,胆是诱发AP的主要因素之一因此早期识别胆道病变预防AP至关重要的手段之一早期的诊断及干预可避免并发症的发生疾病的复发。在急性胆汁性胰腺炎(ABP)并发胆管炎和胆道梗阻时,建议早期进行内窥镜逆行胰胆管造影检查,否则将导致病情的延误及胆道并发症的发生

严重程度分期是入院后AP管理的强制性步骤之一。腹部CT扫描由于可以显示急性胰腺水肿和坏死,因此仍然是临床进行病情严重程度评估的重要基石之一据我们所知,CT对明确病因的价值尚不明确

近日,发表在Radiology杂志的一项研究评估与ABP相关的腹部CT影像学特征,并评估CT征象和临床数据相结合的预测价值,首次发作AP的病因确定提供了参考依据实现了AP患者的早期治疗及预后的提高

从2014年12月到2019年5月,本研究对所有首次出现AP并有至少6个月随访记录的患者进行了评估。胆结石是ABP临床诊断所必须的一项。腹部CT图像由两名腹部放射科医生进行审阅。进行了单变量和多变量统计分析,并在临床数据和CT特征的基础上构建了一个列线图,在另一个独立的内部患者群中进行了验证。

共评估了271名患者(平均年龄±标准差,56岁±20岁;160名男性)。其中,170人(63%)有ABP。在多变量分析中,年龄(几率[OR],1.06;95% CI:1.03,1.09;P < .001)、丙氨酸转氨酶水平(OR,1.00;95% CI:1.00,1.01;P = .009)、胆囊胆石(OR,15.59;95% CI:4.61,68.62;P < . 001)、胆道环征(OR,5.73;95% CI:2.11,17.05;P < .001)、肝脏自发性衰减(OR,1.07;95% CI:1.04,1.11;P < .001)和十二指肠增厚(OR,0.17;95% CI:0.03,0.61;P = .01)都与ABP独立相关。结合临床数据和CT特征的匹配列线图在研究样本(n = 271)中显示了0.94(95% CI: 0.91, 0.97)的曲线下面积,在验证队列(n = 51)中0.91(95% CI: 0.84, 0.99)。

 

 (A, B)研究样本(A)和验证队列(B)中诊断急性胆汁性胰腺炎(ABP)的临床模型、CT模型和联合模型的曲线下面积(AUC)。在研究样本和验证队列中,联合模型显示了预测ABP的最佳诊断性能(AUC,0.91[95% CI:0.818,0.986])。*=AUC与Delong测试的比较。(C, D)研究样本(C)和验证队列(D)中组合模型的校准曲线。

本研究表明急性胰腺炎(AP)的部分早期腹部CT征象为诊断急性胆汁性胰腺炎(ABP)提供了十分有力支持。CT表现和临床数据的结合表现出了对AP胆道因素的最佳诊断性能。由于ABP的早期诊断至关重要,因此本研究认为腹部CT应被纳入ABP早期诊断的一线检查手段由于现阶段CT更多的用于评估AP的严重程度,然而其对病因学诊断的贡献不应该被忽视,这可减少患者不必要的检查并提高患者的治疗预后

原文出处

Thibaut Zver,Paul Calame,Stéphane Koch,et al.Early Prediction of Acute Biliary Pancreatitis Using Clinical and Abdominal CT Features.DOI:10.1148/radiol.2021210607

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    2022-01-13 寒寒子

    学习了

    0

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    2022-01-12 ms6000002088801177

    优秀的

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1758994, encodeId=c63e1e5899469, content=<a href='/topic/show?id=39e96195411' target=_blank style='color:#2F92EE;'>#标本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61954, encryptionId=39e96195411, topicName=标本)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45f437392611, createdName=ms306040998833292, createdTime=Wed Sep 21 21:53:24 CST 2022, time=2022-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1214498, encodeId=f7641214498fc, content=<a href='/topic/show?id=9942839e1ef' target=_blank style='color:#2F92EE;'>#胰腺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83971, encryptionId=9942839e1ef, topicName=胰腺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=赛华佗, createdTime=Tue Apr 26 13:41:39 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595683, encodeId=dc2d159568394, content=<a href='/topic/show?id=ec7c5485b0' target=_blank style='color:#2F92EE;'>#CT表现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5485, encryptionId=ec7c5485b0, topicName=CT表现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=97b318291922, createdName=smallant2008, createdTime=Fri Jan 14 00:53:24 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183774, encodeId=6c6a1183e7495, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=35305534934, createdName=寒寒子, createdTime=Thu Jan 13 08:08:50 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183575, encodeId=bd2811835e594, content=优秀的, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a6316446470, createdName=ms6000002088801177, createdTime=Wed Jan 12 17:38:38 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183542, encodeId=a4bd118354210, content=非常感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be6a2227371, createdName=12116ff9m13(暂无昵称), createdTime=Wed Jan 12 15:42:30 CST 2022, time=2022-01-12, status=1, ipAttribution=)]
    2022-01-12 12116ff9m13(暂无昵称)

    非常感谢

    0

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