JAMA Netw Open:使用雄激素受体抑制剂治疗前列腺癌男性的跌倒和骨折风险

2020-11-29 AlexYang MedSci原创

有报道称,在接受雄激素受体抑制剂(ARI)治疗的患者亚群中,跌倒和骨折的发生率较高,但接受ARI治疗的患者跌倒和骨折的相对风险(RR)尚不清楚。最近,有研究人员评估了接受ARI治疗是否与前列腺癌患者跌

有报道称,在接受雄激素受体抑制剂(ARI)治疗的患者亚群中,跌倒和骨折的发生率较高,但接受ARI治疗的患者跌倒和骨折的相对风险(RR)尚不清楚。最近,有研究人员评估了接受ARI治疗是否与前列腺癌患者跌倒和骨折的相对风险升高有关。

他们的研究中共有11项研究符合本入选标准。总共包括了11382名男性(中位[范围]年龄:72[43-97]岁),其中ARI组6536人,对照组4846人。ARI组的参与者接受恩杂鲁胺、阿帕鲁胺或达鲁胺联合雄激素剥夺疗法或其他恩杂鲁胺组合治疗;对照组的患者接受安慰剂、比卡鲁胺或阿比特龙治疗。ARI组报告的跌倒发生次数为525次(8%),对照组为221次(5%)。骨折的发生次数在ARI组为242次骨折(4%),对照组为107次骨折(2%)。ARI的使用与跌倒和骨折风险增加相关:全级跌倒(RR,1.8;95%CI,1.42-2.24;P<0.001);3级或更高的跌倒(RR,1. 6;95%CI,1.27-2.08;P<0 .001);全级骨折(RR,1.59;95%CI,1.35-1.89;P< 0.001),以及可能的3级或以上骨折(RR,1.71;95%CI,1.12-2.63;P=0.01)。

最后,研究人员指出,ARI的使用与前列腺癌患者跌倒和骨折的增加有关。还需要进一步的研究来确定和理解潜在的机制,并开发策略来减少与ARI使用相关的跌倒和骨折。

原始出处:

Zin W Myint , Harry D Momo, Danielle E Otto et al. Evaluation of Fall and Fracture Risk Among Men With Prostate Cancer Treated With Androgen Receptor Inhibitors: A Systematic Review and Meta-analysis. JAMA Netw Open. Nov 2020

 

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    2021-02-09 jklm09
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    2021-04-30 feather89
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style='color:#2F92EE;'>#骨折#</a>的发生率较高,但是,使用雌激素拮抗剂,同样会使骨折增加,<a href='/topic/show?id=fd3a1018623d' target=_blank style='color:#2F92EE;'>#骨质疏松#</a>风险增加有关。表明<a href='/topic/show?id=c55098e5612' target=_blank style='color:#2F92EE;'>#雌激素#</a>与<a href='/topic/show?id=53d4986867f' target=_blank style='color:#2F92EE;'>#雄激素#</a>,二者一阴一阳,对骨质同样重要!这与<a href='/topic/show?id=c01b2138812' target=_blank style='color:#2F92EE;'>#中医#</a>中治疗骨质疏松,需要阴阳双补是吻合的, beContent=null, objectType=article, channel=null, level=null, likeNumber=266, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98692, encryptionId=f44c98692f9, topicName=雄激素受体抑制剂), TopicDto(id=93034, encryptionId=e201930348f, topicName=跌倒), TopicDto(id=101675, encryptionId=3c531016e571, topicName=骨折), TopicDto(id=101862, encryptionId=fd3a1018623d, topicName=骨质疏松), TopicDto(id=98756, encryptionId=c55098e5612, topicName=雌激素), TopicDto(id=98686, encryptionId=53d4986867f, topicName=雄激素), TopicDto(id=21388, encryptionId=c01b2138812, topicName=中医)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Wed Dec 02 11:56:25 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350581, encodeId=483713505811b, content=<a href='/topic/show?id=a7689869104' target=_blank style='color:#2F92EE;'>#雄激素受体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98691, encryptionId=a7689869104, topicName=雄激素受体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Dec 01 12:40:55 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390427, encodeId=ca4f139042eef, content=<a href='/topic/show?id=22c6101695c9' target=_blank style='color:#2F92EE;'>#骨折风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101695, encryptionId=22c6101695c9, topicName=骨折风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Tue Dec 01 12:40:55 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903501, encodeId=ba1f9035015a, content=有研究人员评估了接受ARI治疗是否与前列腺癌患者跌倒和骨折的相对风险升高有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Mon Nov 30 10:25:39 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903424, encodeId=2a77903424a8, content=是因为雄激素参与了骨的形成?, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201130/be6d5e6ab4a1430aa3d154e79ebfbf74/8e3a836833b041f48050b99f3d0f2022.jpg, createdBy=dafe5224615, createdName=爱读书的大丽子, createdTime=Mon Nov 30 00:28:14 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903475, encodeId=b0409034e5a6, content=ARI的使用与前列腺癌患者跌倒和骨折的增加有关。还需要进一步的研究来确定和理解潜在的机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Mon Nov 30 09:29:12 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903457, encodeId=846490345e1d, content=ARI的使用与前列腺癌患者跌倒和骨折的增加有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 30 08:19:05 CST 2020, time=2020-11-30, status=1, ipAttribution=)]
    2021-05-29 canlab
  4. 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createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Mon Nov 30 09:29:12 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903457, encodeId=846490345e1d, content=ARI的使用与前列腺癌患者跌倒和骨折的增加有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 30 08:19:05 CST 2020, time=2020-11-30, status=1, ipAttribution=)]
    2020-12-02 lifefamily

    在接受#雄激素受体抑制剂#(ARI)治疗的患者亚群中,#跌倒##骨折#的发生率较高,但是,使用雌激素拮抗剂,同样会使骨折增加,#骨质疏松#风险增加有关。表明#雌激素##雄激素#,二者一阴一阳,对骨质同样重要!这与#中医#中治疗骨质疏松,需要阴阳双补是吻合的

    0

  5. 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    2020-11-30 Jessie Zhang

    有研究人员评估了接受ARI治疗是否与前列腺癌患者跌倒和骨折的相对风险升高有关。

    0

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    2020-11-30 爱读书的大丽子

    是因为雄激素参与了骨的形成?

    1

    展开1条回复
  9. [GetPortalCommentsPageByObjectIdResponse(id=1852550, encodeId=cd4118525505d, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Feb 09 10:40:55 CST 2021, time=2021-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728727, encodeId=85081e28727a7, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, 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    2020-11-30 神盾医疗局局长Jack

    ARI的使用与前列腺癌患者跌倒和骨折的增加有关。还需要进一步的研究来确定和理解潜在的机制

    0

  10. 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    2020-11-30 Oranhyg

    ARI的使用与前列腺癌患者跌倒和骨折的增加有关

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