World J Gastroenterology:急性肠系膜静脉血栓形成患者行不可逆肠切除的预测因素

2020-09-20 MedSci原创 MedSci原创

急性肠系膜静脉血栓形成(AMVT)占急性肠系膜缺血病例的5%至15%,并且具有高达10%的死亡率。

        急性肠系膜静脉血栓形成(AMVT)占急性肠系膜缺血病例的5%至15%,并且具有高达10%的死亡率。AMVT的特征是起病隐匿,进展迅速,并且在早期阶段出现非特异性腹部症状。不可逆性肠缺血的发生严重影响了AMVT的预后。AMVT治疗的主要目标是及早进行再通,以预防不可逆的肠缺血的发生。立即抗凝是治疗策略的第一步和基石,早期抗凝已被证明导致> 80%的血管再通和降低死亡率,但是,对于肠坏死和严重脓毒症的患者,最终可能需要控制损伤的剖腹手术,包括肠切除术和开腹术,一些研究表明,积极的经导管溶栓(TT)可以改善AMVT的治疗结果,然而,不可逆的肠缺血仍是预后不良的主要原因,不可逆性肠缺血的危险因素尚不清楚,本项研究旨在评估TT治疗的AMVT患者中需要手术切除的不可逆性肠缺血的临床结果并确定预测因素。

 

        研究人员回顾性分析了2010年1月至2017年10月连续接受TT治疗的AMVT患者的临床记录。并将要切除不可逆性肠缺血的患者与不需要切除肠的患者进行了比较。

 

        研究发现在58例患者中,所有患者在入院后28.5 h进行了即时TT。共有42例(72.4%)患者接受了动静脉联合溶栓治疗,而16例(27.6%)仅接受了动脉溶栓治疗。30天总死亡率为8.6%。32例(55.2%)的患者出现不可逆的肠缺血,与未切除的患者相比,其30 d的死亡率更高、住院时间更长。不可逆性肠缺血的重要独立预测因素是急性生理和慢性健康评估(APACHE)II评分(优势比= 2.368,95%CI:1.047-5.357,P = 0.038)和白细胞增多症(优势比= 2.058,95%CI:1.085-3.903,P= 0.027)。

 

        研究最后研究人员说道:及时的TT可以在AMVT患者中取得良好的疗效。高APACHE II评分和白细胞增多可以显着预测不可逆性肠缺血的发生。

 

 

原始出处:

Shi-Long Sun. Et al. Predictors of irreversible intestinal resection in patients with acute mesenteric venous thrombosis. World J Gastroenterology.2020.

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    2021-08-09 fusion
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createdBy=0bed488, createdName=jktdtl, createdTime=Thu Nov 05 20:27:17 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003958, encodeId=a85a20039581c, content=<a href='/topic/show?id=6d568161850' target=_blank style='color:#2F92EE;'>#肠系膜静脉血栓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81618, encryptionId=6d568161850, topicName=肠系膜静脉血栓)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e080359, createdName=surilei, createdTime=Tue May 11 03:27:17 CST 2021, time=2021-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712546, encodeId=da071e125466e, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Mon Jan 25 04:27:17 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073106, encodeId=e95f20e3106d2, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Jan 09 20:27:17 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955507, encodeId=24f0195550e50, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Sat Oct 10 03:27:17 CST 2020, time=2020-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264338, encodeId=1af01264338fb, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Tue Sep 22 06:27:17 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483295, encodeId=26fc14832954e, content=<a 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22 06:27:17 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557269, encodeId=1bc0155e26993, content=<a href='/topic/show?id=d5e281610db' target=_blank style='color:#2F92EE;'>#肠系膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81610, encryptionId=d5e281610db, topicName=肠系膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f84f14890130, createdName=zzc2216, createdTime=Tue Sep 22 06:27:17 CST 2020, time=2020-09-22, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1698144, encodeId=31eb169814450, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Mon Aug 09 06:27:17 CST 2021, time=2021-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065149, encodeId=5ad920651499a, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, 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channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Sat Oct 10 03:27:17 CST 2020, time=2020-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264338, encodeId=1af01264338fb, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Tue Sep 22 06:27:17 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483295, encodeId=26fc14832954e, content=<a href='/topic/show?id=c82e991e71b' target=_blank style='color:#2F92EE;'>#静脉血栓形成#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99177, encryptionId=c82e991e71b, topicName=静脉血栓形成)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d387907505, createdName=ms5187542471278033, createdTime=Tue Sep 22 06:27:17 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505081, encodeId=e7f715050814f, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Sep 22 06:27:17 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557269, encodeId=1bc0155e26993, content=<a href='/topic/show?id=d5e281610db' target=_blank style='color:#2F92EE;'>#肠系膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81610, encryptionId=d5e281610db, topicName=肠系膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f84f14890130, createdName=zzc2216, createdTime=Tue Sep 22 06:27:17 CST 2020, time=2020-09-22, status=1, ipAttribution=)]
    2021-01-09 许安
  6. [GetPortalCommentsPageByObjectIdResponse(id=1698144, encodeId=31eb169814450, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Mon Aug 09 06:27:17 CST 2021, time=2021-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065149, encodeId=5ad920651499a, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, 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22 06:27:17 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557269, encodeId=1bc0155e26993, content=<a href='/topic/show?id=d5e281610db' target=_blank style='color:#2F92EE;'>#肠系膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81610, encryptionId=d5e281610db, topicName=肠系膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f84f14890130, createdName=zzc2216, createdTime=Tue Sep 22 06:27:17 CST 2020, time=2020-09-22, status=1, ipAttribution=)]
    2020-10-10 xue8602
  7. 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    2020-09-22 zzc2216

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