NEJM:一种新发现的与人体发热相关的片段RNA病毒

2019-05-31 MedSci MedSci原创

研究认为,一种新发现的片段病毒与中国东北地热病有关

2017年,中国发生了一例疑似蜱传疾病,该病人在内蒙古一家医院就诊,其发热原因不明,临床表现与蜱传脑炎病毒 (TBEV)相似,但未检测到TBEV RNA和抗病毒抗体。

近日研究人员获得了患者血液样本,并尝试使用基因组序列分析和电子显微镜分离和鉴定致病病原体。研究人员还在同一家医院启动了一项加强监控计划,以筛查出现发烧,头痛和蜱叮咬病史的其他患者。采用逆转录酶 - 聚合酶-链反应(RT-PCR)和细胞培养法检测病原体、免疫荧光和中和试验,检测患者血清中病毒特异性抗体的水平。

研究发现,该患者感染了一种以前未知的片段RNA病毒,研究人员将其命名为Alongshan病毒(ALSV),属于黄病毒科Jingmenvirus组。对86例内蒙古、黑龙江地区有发热、头痛、蜱叮咬史的患者进行了RT-PCR检测,并确认了ALSV感染。血清学检查显示,所有19名病人均发生血清转化,这些标本可从疾病的急性期和恢复期获得。

研究认为,一种新发现的片段病毒与中国东北地热病有关。

原始出处:

Ze-Dong Wang et al. A New Segmented Virus Associated with Human Febrile Illness in China. N Engl J Med, May 30, 2019

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