看!中草药在多囊卵巢综合征发光发热!

2021-11-21 August MedSci原创

多囊卵巢综合征 (PCOS) 是无排卵性不孕症的最常见原因之一。中草药(CHM)在治疗多囊卵巢综合征方面具有许多优势。

多囊卵巢综合征 (PCOS) 是女性最常见的内分泌和代谢疾病,影响约 8-13% 的育龄女性。表现具有异质性,通常以月经稀发和排卵功能障碍、临床或生化雄激素过多和多囊卵巢形态为特征。伴有异常的代谢和心理特征。PCOS 占无排卵性不孕症病例的 80%。如果患有 PCOS 的女性对一线或二线促排卵治疗或其他适应症反应不佳,则需要进行体外受精 (IVF)。然而,接受 IVF 的 PCOS 患者的着床率、临床妊娠率和活产率较低,但发生卵巢过度刺激综合征 (OHSS)、产科并发症和新生儿并发症的风险较高。

由于大多数传统西药仅含有单一活性成分,因此它们解决 PCOS 各种症状的能力有限。中草药 (CHM) 在治疗 PCOS 患者的妇科问题和不孕症方面有着悠久的历史。作为一种整体医学,中草药的优势在于多种草药组合在一个配方中,因此可以同时针对生殖和代谢缺陷。多项研究证明,作为生活方式干预或传统药物的联合治疗,中草药可以改善多囊卵巢综合征的不同方面,例如将血清激素改变到正常水平,促进月经规律和排卵,提高受孕率,提高胰岛素敏感性,调节糖脂代谢,减少炎症反应和氧化应激。因此,如今 CHM 在患有 PCOS 的女性中越来越受欢迎。此研究旨在调查补肾天经方(BSTJF)对中国多囊卵巢综合征患者体外受精结果的影响及其潜在的潜在机制。

方法:共纳入 2009 年 11 月至 2018 年 7 月期间接受试管婴儿的 111 名 PCOS 患者。54 名患者在控制卵巢过度刺激之前接受了为期三个月的补肾天经方(BSTJF)治疗,而其他 57 名患者没有。收集了 PCOS 患者的数据。评估了卵泡液中的抗苗勒管激素 (AMH)、生长分化因子-8 (GDF-8) 水平。

结果:BSTJF 帮助多囊卵巢综合征患者获得更多的卵母细胞(P<0.05)和受精卵母细胞(P<0.05)。BSTJF治疗的PCOS患者在同一刺激周期的临床累积妊娠率、活产率和足月分娩率均显着升高(P<0.05)。两组受精率、卵巢过度刺激综合征住院率、产科或新生儿并发症无显着差异。BSTJF显着降低卵泡液中的AMH水平(P<0.05)。

回顾性研究结果表明,中医药对中国多囊卵巢综合征患者的试管婴儿结局有积极影响。可能的原因在于,CHM 可以帮助 PCOS 患者取回更多的卵母细胞并获得更多的受精卵母细胞。有了更多的胚胎,他们就有更多的机会进行胚胎移植,从而有更多的机会怀孕。上述证据表明 CHM 是接受 IVF 的 PCOS 患者的良好且安全的干预措施,这与先前的研究一致。为得到更可靠的结论,应进行前瞻性、多中心、大样本的随机对照临床试验,并应用多种生物样本(如血清、颗粒细胞、胎盘)进行研究。此外,应该更加关注中草药对接受IVF的PCOS患者后代的长期影响。

总之,补肾天经方可通过降低卵泡液中的AMH水平来改善中国PCOS患者IVF的妊娠结局。然而,由于样本量小和几个潜在的偏差,结果是有限的。

 

原文:Pan X, Gu Y, Zhang X, et al. Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: a retrospective cohort study. Integr Med Res. 2022;11(1):100775. doi:10.1016/j.imr.2021.100775

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    2021-11-24 Lee4204

    学习

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1718454, encodeId=0b1f1e184549b, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Tue Apr 19 21:15:04 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754693, encodeId=e5dd1e5469323, content=<a href='/topic/show?id=b5338e217cd' target=_blank style='color:#2F92EE;'>#草药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87217, encryptionId=b5338e217cd, topicName=草药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff5b36776883, createdName=zll0637, createdTime=Fri Oct 07 21:15:04 CST 2022, time=2022-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206043, encodeId=e3131206043bb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=590d5152143, createdName=1469b347m69暂无昵称, createdTime=Sat Mar 26 08:41:27 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1073401, encodeId=777a10e340192, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/KVHctYzJg2NRamomawmLicXkx2wOqTxoncJfTCraj1ff7K7gG5lr8u9wyzCUVMMW5T6JPibpuKF6OPicV5YiaWFqew/132, createdBy=65c65253420, createdName=Lee4204, createdTime=Wed Nov 24 08:07:48 CST 2021, time=2021-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1073180, encodeId=798010e318023, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>努力更新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=bcb05196903, createdName=1472b47dm95暂无昵称, createdTime=Tue Nov 23 13:46:51 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1432194, encodeId=e0b51432194d6, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Nov 22 15:15:04 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1072830, encodeId=29c510e2830d2, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=045d5726748, createdName=ms1000001296349559, createdTime=Mon Nov 22 13:00:15 CST 2021, time=2021-11-22, status=1, ipAttribution=)]
    2021-11-23 1472b47dm95暂无昵称

    #学习#努力更新知识

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1718454, encodeId=0b1f1e184549b, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Tue Apr 19 21:15:04 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754693, encodeId=e5dd1e5469323, content=<a href='/topic/show?id=b5338e217cd' target=_blank style='color:#2F92EE;'>#草药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87217, encryptionId=b5338e217cd, topicName=草药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff5b36776883, createdName=zll0637, createdTime=Fri Oct 07 21:15:04 CST 2022, time=2022-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206043, encodeId=e3131206043bb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=590d5152143, createdName=1469b347m69暂无昵称, createdTime=Sat Mar 26 08:41:27 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1073401, encodeId=777a10e340192, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/KVHctYzJg2NRamomawmLicXkx2wOqTxoncJfTCraj1ff7K7gG5lr8u9wyzCUVMMW5T6JPibpuKF6OPicV5YiaWFqew/132, createdBy=65c65253420, createdName=Lee4204, createdTime=Wed Nov 24 08:07:48 CST 2021, time=2021-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1073180, encodeId=798010e318023, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>努力更新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=bcb05196903, createdName=1472b47dm95暂无昵称, createdTime=Tue Nov 23 13:46:51 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1432194, encodeId=e0b51432194d6, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Nov 22 15:15:04 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1072830, encodeId=29c510e2830d2, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=045d5726748, createdName=ms1000001296349559, createdTime=Mon Nov 22 13:00:15 CST 2021, time=2021-11-22, status=1, ipAttribution=)]
    2021-11-22 ms1000001296349559

    #学习#学习

    0

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