Diabetes Care:非酒精性脂肪肝在孕前糖尿病妇女中很常见!

2016-11-07 haofan MedSci原创

NAFLD在这些比较年轻,肥胖不太严重的PGDM妇女中较为常见。而胰岛素抵抗及腰围与NAFLD的发生独立相关,而与葡萄糖不耐受无关。

有研究表明2型糖尿病会增加非酒精性脂肪性肝(NAFLD)的发生风险,NAFLD是一个潜在的可逆性疾病,可以进行性发展为肝脏纤维化和肝硬化。近日,糖尿病领域权威杂志Diabetes Care发表了一篇研究文章,旨在确定孕前糖尿病(PGDM)的孕妇发生NAFLD的风险。

该研究共纳入100名已经确诊无糖尿病的PGDM患者(她们各项指标的中位数[间距范围]:年龄为38.6[6.4]岁;体重指数为:31.0[6.2]kg/m2)和11名无NAFLD的健康对照者(年龄为37.9[7.8]岁;体重指数为28.1[0.8] kg/m2),研究人员对这些参与者进行75g的口服葡萄糖耐量试验(OGTT),DXA全身扫描评估内脏脂肪含量,肝脏超声检查评估脂肪肝情况。

研究者通过肝脏超声检查发现了24(24%)名PGDM患者出现了NAFLD,没有一例患者出现肝硬化。进一步分析发现发生NAFLD的妇女体重指数(P=0.0002)和腰围(P=0.0003)都较大,胰岛素抵抗也明显增加(P=0.0004)和OGTT后胰高血糖素抑制延迟更加明显(P<0.0001),但NAFLD与葡萄糖不耐受的程度并不相关(P=0.2196)。各组的内脏脂肪重量也有所不同,在发生了NAFLD的孕妇中内脏脂肪含量最多,而对照组的脂肪含量最低(P=0.0003)。最后,研究人员通过Logistic回归分析,发现胰岛素抵抗(P=0.0057)和腰围(P=0.0109)与PGDM患者NAFLD的发生独立相关。

由此可见,NAFLD在这些比较年轻、轻微肥胖的PGDM妇女中较为常见。另外,胰岛素抵抗及腰围与NAFLD的发生独立相关,而与葡萄糖不耐受无关。

原始出处:

Signe Foghsgaard,et al. Nonalcoholic Fatty Liver Disease Is Prevalent in Women With
Prior Gestational Diabetes Mellitus and Independently Associated With Insulin
Resistance and Waist Circumference
. Diabetes Care. 2016 Nov; dc161017

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  5. 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createdName=ylzr123, createdTime=Sun Nov 13 20:52:54 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154504, encodeId=b0341545042b, content=挺好的 很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38ca1978307, createdName=1e178a83m73(暂无匿称), createdTime=Wed Nov 09 07:59:44 CST 2016, time=2016-11-09, status=1, ipAttribution=)]
    2017-06-05 szhvet
  6. [GetPortalCommentsPageByObjectIdResponse(id=1759810, encodeId=0e741e5981042, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Feb 18 12:41:00 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676303, encodeId=e5b216e6303dd, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  7. 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  8. 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createdName=ylzr123, createdTime=Sun Nov 13 20:52:54 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154504, encodeId=b0341545042b, content=挺好的 很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38ca1978307, createdName=1e178a83m73(暂无匿称), createdTime=Wed Nov 09 07:59:44 CST 2016, time=2016-11-09, status=1, ipAttribution=)]
    2016-11-30 镱鉎鉌釚

    非酒精性脂肪肝在孕前糖尿病妇女中很常见!

    0

  9. 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createdName=ylzr123, createdTime=Sun Nov 13 20:52:54 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154504, encodeId=b0341545042b, content=挺好的 很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38ca1978307, createdName=1e178a83m73(暂无匿称), createdTime=Wed Nov 09 07:59:44 CST 2016, time=2016-11-09, status=1, ipAttribution=)]
    2016-11-13 ylzr123

    NAFLD在这些比较年轻、轻微肥胖的PGDM妇女中较为常见。另外,胰岛素抵抗及腰围与NAFLD的发生独立相关,而与葡萄糖不耐受无关。

    0

  10. 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createdName=ylzr123, createdTime=Sun Nov 13 20:52:54 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154504, encodeId=b0341545042b, content=挺好的 很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38ca1978307, createdName=1e178a83m73(暂无匿称), createdTime=Wed Nov 09 07:59:44 CST 2016, time=2016-11-09, status=1, ipAttribution=)]
    2016-11-09 1e178a83m73(暂无匿称)

    挺好的 很有用

    0

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非酒精性脂肪肝病(NAFLD)是美国儿童的主要慢性肝病,与胰岛素抗性相关。在成年人中,NAFLD也与2型糖尿病相关。然而,2型糖尿病在NAFLD儿童中的发病率是未知的。为了确定2型糖尿病和糖尿病前期在NAFLD儿童中的患病率,并评估2型糖尿病和前期糖尿病作为非酒精性脂肪性肝炎(NASH)的风险因素,来自美国的研究人员开展了一项研究。这是一项多中心横断面研究,在美国的12个儿科临床中心进行。这些儿童