medRxiv: SHERLOCK新冠检测:24例阴性样本检出18例“复阳”

2020-04-02 生物探索 生物探索

一些新冠肺炎(COVID-19)患者出院后会出现复阳的情况。最新一项发表在预印本网站 medRxiv的研究或许找到了答案——目前商用试剂盒检测带来的假阴性可能是导致 &ldqu

一些新冠肺炎(COVID-19)患者出院后会出现复阳的情况。最新一项发表在预印本网站 medRxiv的研究或许找到了答案——目前商用试剂盒检测带来的假阴性可能是导致 “复阳” 的原因。

研究人员分析了于 2020 年 1 月 23 日至 2 月 25 日出院的 262 例COVID-19患者。截至 2020 年 3 月 10 日,所有患者接受了至少 14 天的随访。结果发现,38例“复阳”患者,占比为 14.5%。

此外,研究人员在使用“CRISPR基因编辑大神”张锋实验室的 SHERLOCK 试剂盒检测后发现,目前商业试剂盒检测结果为阴性的 24 个样品中,有 18 个样本呈阳性。

当地时间2月14日,美国麻省理工学院Broad研究所联合哈佛大学、麻省理工学院McGovern研究所以及其相关合作机构宣布,张锋教授、Omar Abudayyeh和Jonathan Gootenberg开发了一种基于SHERLOCK的COVID-19诊断技术。该技术具有特异的高灵敏度,每微升里仅10-100个病毒拷贝,就可以被检测出来。且步骤简单,只需三步,一小时内就可以完成检测。

这项研究结果表明,已经治愈的新冠肺炎患者仍可能携带新冠病毒,为恢复期新冠患者的有效管理提供了关键信息。

原始出处:
Jianghong An,et al. Clinical characteristics of the recovered COVID-19 patients with re-detectable positive RNA test. medRxiv. Posted March 30, 2020.

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    2020-08-31 zhzhxiang
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    2020-04-04 智慧医人
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    2020-04-03 公卫新人

    新冠肺炎,疫情何时才能消失

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