Clin Exp Allergy:学龄早期儿童的总抗氧化能力与随后的过敏性疾病有何关系?

2017-06-04 xing.T MedSci原创

由此可见,在学龄早期膳食中TAC较高可能会降低从童年到青春期对吸入性过敏原敏感的风险。这些研究结果表明在儿童时期选择抗氧化剂丰富的饮食可能有助于预防过敏性疾病。

膳食中抗氧化剂摄入量已被假设会影响过敏性疾病的发展,但是,很少有前瞻性研究对这一相关性进行了研究。近日,过敏性疾病领域权威杂志Clinical and Experimental Allergy上发表了一篇研究文章,研究人员旨在评估8岁时膳食中总抗氧化能力(TAC)8岁时和随后8-16岁期间哮喘、鼻炎和吸入性过敏原敏感发生之间的相关性,并评估已知风险因素的潜在效应改变。
 
研究人员共纳入了来自于瑞典的出生队列BAMSE的2359名儿童。受试者8岁时膳食中TAC采用通过食物频率问卷调查过去的12个月内儿童饮食信息与通过氧自由基吸收能力的方法分析常见的食物数据库相结合。哮喘和鼻炎的分类是基于问卷调查,并测量了8-16岁儿童血清中的IgE抗体水平。
 
研究人员发现膳食中的TAC与吸入性过敏原敏感之间存在显著负相关(第3三分位数相比于第1三分位数,调整后的比值比为0.73,95%可信区间为0.55-0.97,趋势P值=0.031)。研究人员发现交通相关的空气污染会改变这种效应,在低交通相关空气污染暴露的儿童中,膳食TAC和敏感之间具有更强的相关性(相互作用P=0.029)。没有证据表明GSTP1或TNF基因型会引起效应改变,虽然这些结果应谨慎解释。没有观察到TCA与鼻炎或哮喘的发生发展之间存在明确的相关性,尽管在过敏性哮喘中可以观察到显著的负相关(调整后的比值比为0.57,95%可信区间为0.34-0.94)。
 
由此可见,在学龄早期膳食中TAC较高可能会降低从童年到青春期对吸入性过敏原敏感的风险。这些研究结果表明在儿童时期选择抗氧化剂丰富的饮食可能有助于预防过敏性疾病。
 
原始出处:
 
A. Gref,et al. Dietary total antioxidant capacity in early school age and subsequent allergic disease.Clin Exp Allergy. 2017. http://onlinelibrary.wiley.com/doi/10.1111/cea.12911/full
 
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    2017-06-07 zhangqingzui

    好好学习,感谢分析

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content=抗氧化剂摄入量会影响过敏性疾病的发展。, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Mon Jun 05 08:36:24 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206739, encodeId=b029206e3989, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Jun 05 08:12:42 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206737, encodeId=4e1b206e376a, content=好好学习,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jun 05 08:07:29 CST 2017, time=2017-06-05, status=1, ipAttribution=)]
    2017-06-06 膀胱癌
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    2017-06-06 zhangqingzui

    好好学习,

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206737, encodeId=4e1b206e376a, content=好好学习,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jun 05 08:07:29 CST 2017, time=2017-06-05, status=1, ipAttribution=)]
    2017-06-05 明天会更好!

    好好学习,感谢分享

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206737, encodeId=4e1b206e376a, content=好好学习,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jun 05 08:07:29 CST 2017, time=2017-06-05, status=1, ipAttribution=)]
    2017-06-05 童小孩

    学习

    0

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    2017-06-05 Julie W

    在学龄早期膳食中TAC较高可能会降低从童年到青春期对吸入性过敏原敏感的风险。这些研究结果表明在儿童时期选择抗氧化剂丰富的饮食可能有助于预防过敏性疾病。

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206737, encodeId=4e1b206e376a, content=好好学习,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jun 05 08:07:29 CST 2017, time=2017-06-05, status=1, ipAttribution=)]
    2017-06-05 邓启付

    抗氧化剂摄入量会影响过敏性疾病的发展。

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206737, encodeId=4e1b206e376a, content=好好学习,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jun 05 08:07:29 CST 2017, time=2017-06-05, status=1, ipAttribution=)]
    2017-06-05 明月清辉

    谢谢分享,学习了

    0

  10. 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    2017-06-05 zhangqingzui

    好好学习,感谢分享

    0

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