Eur Urol：3期| 帕唑帕尼用作晚期肾癌患者肾切除术后辅助治疗的疗效

2021-03-01 MedSci原创 MedSci原创

大多数研究表明，VEGFR酪氨酸激酶抑制剂辅助治疗晚期肾癌(RCC)没有任何益处。

大多数研究表明，VEGFR酪氨酸激酶抑制剂辅助治疗晚期肾癌(RCC)没有任何益处。

PROTECT(NCT01235962)是一项随机、双盲、安慰剂对照的3期研究，旨在评估帕唑帕尼(pazopanib)用于肾切除术后有高复发风险的局部晚期肾癌患者的疗效。共招募了1538位患者，1:1随机分至帕唑帕尼组和安慰剂组(各 769位患者)。

初步分析结果显示，帕唑帕尼(600 mg)治疗与安慰剂相比在无病生存率方面没有明显差异。本文报告了该研究最终的总存活率(OS)分析。

帕佐帕尼组和安慰剂组分别中位随访了76个月和77个月。帕唑帕尼组和安慰剂组的OS没有显著差异(风险比 1.0，95%CI 0.80-1.26；P>0.9)。

与病情较轻的患者相比，T4期患者的OS较差。

体重指数(BMI)≥30 kg/m2的患者与BMI较低的患者相比，OS较好。

与那些在治疗后2年内复发的患者相比，治疗后2年内仍保持病情稳定的患者的OS明显更好。这些发现与该试验的初步结果一致，表明帕佐帕尼辅助治疗对局部晚期肾癌切除术后的患者的OS没有治疗益处。

总之，本研究表明，局部晚期肾癌患者在肾切除术后，接受帕唑帕尼或安慰剂辅助治疗的复发风险均很高，总体存活率相似。因此，不推荐帕唑帕尼用作局部晚期肾癌切除术后的辅助治疗。

原始出处：

Motzer Robert J,Russo Paul,Haas Naomi et al. Adjuvant Pazopanib Versus Placebo After Nephrectomy in Patients With Localized or Locally Advanced Renal Cell Carcinoma: Final Overall Survival Analysis of the Phase 3 PROTECT Trial. Eur Urol, 2021, 79: 334-338.

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2021-03-12 doctorzheng

#切除术#

21 0
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2021-04-11 tongyongming

#术后辅助治疗#

46 0
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2021-11-20 gaoxiaoe

#肾切除术#

38 0
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2021-03-04 ms2000000322316384

局部晚期是啥

64 0
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2021-03-03 走，走走

这份研究终于出结果了

82 0
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2021-03-03 wujh_7312819

#晚期肾癌#

36 0
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2021-03-01 内科新手

谢谢梅斯提供这么好的信息，学到很多

45 0

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