Neurology:失眠症状与心血管疾病风险

2019-11-08 xing.T MedSci原创

由此可见,单个和共存的失眠症状是CVD发病的独立危险因素,尤其是在年轻人或未患高血压的成年人中。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在探讨中国成年人失眠症状与心脑血管疾病(CVD)风险和可能的调节因素之间的相关性。

中国嘉道理生物库是一项前瞻性队列研究,该研究招募了来自中国10个地区的参与者。研究人员分析了基线时无卒中、冠心病和癌症的487200名30至79岁成年人的数据。研究人员评估了基线时三种失眠症状:自我报告的入睡或维持睡眠困难、清晨苏醒和白天功能障碍。通过疾病登记和国家健康保险数据库对CVD的发生情况进行随访,直至2016年。

在9.6年的中位随访期中,共记录了1300032例CVD病例。Cox回归显示3种失眠症状与总CVD风险增加相关,调整后的风险比(HRs)和95%置信区间(CIs)分别为1.09(95%CI为1.07-1.11)、1.07(95%CI为1.05-1.09)和1.13(95%CI为1.09-1.18)。有个别症状的参与者也有较高的患缺血性心脏病(IHD; HR为1.13、1.09和1.17)和缺血性卒中的风险有关,但与出血性卒中的风险无关。与无症状的成年人相比,具有上述三种症状的参与者患CVD、IHD或缺血性卒中的风险分被高出18%、22%或10%。年轻人或无基线高血压者中3种症状与CVD发生率之间的相关性较强(交互作用P<0.05)。

由此可见,单个和共存的失眠症状是CVD发病的独立危险因素,尤其是在年轻人或未患高血压的成年人中。 

原始出处:

Bang Zheng,et al.Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults A 10-year cohort.Neurology.2019.https://n.neurology.org/content/early/2019/11/06/WNL.0000000000008581

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    2020-09-25 yinhl1978
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    2019-11-10 日月
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