JCEM：维生素D状态和摄入量与认知功能有何关联

2018-02-08 MedSci MedSci原创

大家都知道血清25-羟基维生素D [25（OH）D]、饮食和补充维生素D可能影响认知结果。May A Beydoun等人在大量的种族和社会经济多样的美国城市成年人的各种认知领域的纵向变化检查维生素D状态和摄入量与性别/年龄特定和种族特定的关联，并将研究结果发表在近日的JCEM上。

大家都知道血清25-羟基维生素D [25（OH）D]、饮食和补充维生素D可能影响认知结果。May A Beydoun等人在大量的种族和社会经济多样的美国城市成年人的各种认知领域的纵向变化检查维生素D状态和摄入量与性别/年龄特定和种族特定的关联，并将研究结果发表在近日的JCEM上。

研究人员使用了两个前瞻性的跨越整个生命周期健康老龄化（HANDLS）研究的数据波。对30-64岁的成年美国人进行基线访视，随访时间为1（2004-2009）至2（2009-2013），平均随访时间为±SD：4.64±0.93y。最终的分析样本量为1，231-1，803人，1.5-2.0次随访/受试者。认知表现评估使用包括全球认知、注意力、学习/记忆、执行功能、视空间/视觉建设能力、精神运动速度和语言/口头领域的11个测试分数。血清25（OH）D、维生素D的摄取和补充是主要的暴露因素。

研究结果显示基于多个混合效应线性回归模型，维生素D状况（总体）和补充摄入量（老年妇女和非洲裔美国人）之间的一致关系在言语流畅性领域下降速度较慢。较高的膳食摄入维生素D与年轻女性言语记忆下降速度较慢有关，白人视觉记忆/视觉建构能力下降速度较慢。其他关联不一致。

上述研究表明维生素D状态和摄入量与美国城市成年人的特定领域认知下降呈负相关。需要更大的人口研究来复制该研究结果。

原始出处：

May A Beydoun.et al. Vitamin D Status and Intakes and Their Association with Cognitive Trajectory in A Longitudinal Study of Urban Adults. J Clin Endocrinol Metab. 2017.

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

轻灵划译

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2018-04-14 ms6390871039024434

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2018-06-18 smallant2015

#JCEM#

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2018-12-21 爆笑小医

#摄入量#

23 0
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2018-10-19 achengzhao

#JCE#

24 0
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2018-02-11 三生有幸9135

学习一下谢谢分享

83 0
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2018-02-11 jihuaijun1112

学习学习学习

66 0
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2018-02-10 jyzxjiangqin

维生素D状态和摄入量.

65 0
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2018-02-10 1e1c07bdm01(暂无匿称)

好

65 0
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2018-02-09 happsf

学习

72 0
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2018-02-09 huizi3382

***

28 0