Eur Respir J:轻度至中度阿尔茨海默氏病患者阻塞性睡眠呼吸暂停和认知功能下降

2020-06-21 MedSci原创 MedSci原创

该研究可观察到OSA组的ADAS-cog评分比非OSA组更好,虽有统计学意义,但无临床意义。随访1年后,研究人员在不同的认知亚领域或总体认知方面均未发现差异。

近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员旨在评估了轻度至中度阿尔茨海默氏病(AD)患者未经治疗的阻塞性睡眠呼吸暂停(OSA)对认知下降幅度和几个认知亚领域的影响。

在这项单中心研究中,研究人员从认知障碍科前瞻性地招募了144例患者,并进行过夜多导睡眠图检查。

非OSA组在12个月时的阿尔茨海默病疾病评估量表认知子量表(ADAS-cog)得分为3.19(5.61),而OSA组为0.08(5.62),组间差异为-3.36(95%CI为0.19至0.16; p=0.002)。在12个月时,研究人员在任何认知亚领域中均未观察到显著差异。关于36个月时的迷你精神状态评分,平均变化为1.69(95%CI为-1.26至4.64;p=0.445)。在不同的OSA严重程度组之间未发现显著差异。

由此可见,该研究可观察到OSA组的ADAS-cog评分比非OSA组更好,虽有统计学意义,但无临床意义。随访1年后,研究人员在不同的认知亚领域或总体认知方面均未发现差异。

原始出处:

Carmen Jorge,et al.Obstructive sleep apnoea and cognitive decline in mild-to-moderate Alzheimer's disease.Eur Respir J.2020.https://erj.ersjournals.com/content/early/2020/06/11/13993003.00523-2020

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    2020-07-09 tomyang96
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1696948, encodeId=78251696948ff, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Thu Jul 09 21:03:31 CST 2020, time=2020-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034332, encodeId=125520343326a, content=<a href='/topic/show?id=2fda91215d2' target=_blank style='color:#2F92EE;'>#认知功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91215, encryptionId=2fda91215d2, topicName=认知功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1696948, encodeId=78251696948ff, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Thu Jul 09 21:03:31 CST 2020, time=2020-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034332, encodeId=125520343326a, content=<a href='/topic/show?id=2fda91215d2' target=_blank style='color:#2F92EE;'>#认知功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91215, encryptionId=2fda91215d2, topicName=认知功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, 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GetPortalCommentsPageByObjectIdResponse(id=1990435, encodeId=76741990435fe, content=<a href='/topic/show?id=b8eb9e78216' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97782, encryptionId=b8eb9e78216, topicName=阿尔茨海默氏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Mon Sep 21 09:03:31 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365182, encodeId=fa6913651821d, content=<a href='/topic/show?id=f2049e785f1' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97785, encryptionId=f2049e785f1, topicName=阿尔茨海默氏病)], attachment=null, authenticateStatus=null, createdAvatar=, 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  7. [GetPortalCommentsPageByObjectIdResponse(id=1696948, encodeId=78251696948ff, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Thu Jul 09 21:03:31 CST 2020, time=2020-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034332, encodeId=125520343326a, content=<a href='/topic/show?id=2fda91215d2' target=_blank style='color:#2F92EE;'>#认知功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91215, encryptionId=2fda91215d2, topicName=认知功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, 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GetPortalCommentsPageByObjectIdResponse(id=1990435, encodeId=76741990435fe, content=<a href='/topic/show?id=b8eb9e78216' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97782, encryptionId=b8eb9e78216, topicName=阿尔茨海默氏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Mon Sep 21 09:03:31 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365182, encodeId=fa6913651821d, content=<a href='/topic/show?id=f2049e785f1' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97785, encryptionId=f2049e785f1, topicName=阿尔茨海默氏病)], attachment=null, authenticateStatus=null, createdAvatar=, 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  8. 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