Cardiovasc Diabetol:累积甘油三酯-葡萄糖指数越高,心血管疾病风险越大!

2022-02-20 Nebula MedSci原创

发生心血管疾病的风险随着累积TyG指数的增加而升高

既往研究表明,基线甘油三酯-葡萄糖 (TyG) 指数与心血管疾病 (CVD) 之间存在显著关系。但是,TyG 指数和新发心血管疾病的长期相关性仍不确定。本研究旨在探讨累积 TyG 指数与心血管疾病风险之间的关系。

在这项研究中,招募了 2006 年至 2013 年参加 Kailuan 研究、连续四次检查中没有卒中、心肌梗塞和癌症的个体。通过将平均 TyG 指数乘以两次连续检查之间的时间来计算累积 TyG 指数。根据累积 TyG 指数水平将所有受试者分为四个四分位数组:Q1 组,≤ 50.65(作为参考组);Q2 组,50.65-53.86,Q3 组,53.86-57.44;Q4 组,>?57.44。采用多变量 Cox 比例风险模型估计累积 TyG 指数与心血管疾病风险之间的相关性。

不同累积TyG指数水平个体发生心血管疾病的风险

本次分析共纳入了 44,064 位受试者。中位随访了 6.52±1.14 年后,分别有 2057 位、395 位和 1695 位个体发生过心血管疾病、心肌梗塞和卒中。根据多重潜在的混杂因素调整后,发生心血管疾病的风险随着累积TyG指数的增加而升高,与 Q1 组相比,Q2 组、Q3 组和 Q4 组的风险比(HR)分别是 1.25 (1.08-1.44)、1.22 (1.05-1.40) 和 1.39 (1.21–1.61)。

不同较高累积TyG指数水平暴露时间个体发生心血管疾病的风险

此外,较高 TyG 指数暴露的持续时间较长也与心血管疾病风险增加显著相关。在亚组和敏感性分析中也获得了类似的结果。

综上所述,累积 TyG 指数与心血管疾病风险增加密切相关。将甘油三酯和空腹血糖维持在理想范围内,更好地控制累积 TyG 指数对于预防心血管疾病很重要。

原始出处:

Cui, H., Liu, Q., Wu, Y. et al. Cumulative triglyceride-glucose index is a risk for CVD: a prospective cohort study. Cardiovasc Diabetol 21, 22 (2022). https://doi.org/10.1186/s12933-022-01456-1

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