Thorax:激素避孕药与重度哮喘加重风险的关系

2020-11-26 MedSci原创 MedSci原创

使用激素避孕药可以降低育龄妇女严重哮喘加重的风险。需要进行机制研究,以探究激素避孕药对女性哮喘临床结局影响的生物学基础。

目前,缺乏关于外源性类固醇对女性哮喘临床结局影响的纵向研究。近日,胸部疾病领域权威杂志Thorax上发表了一篇研究文章,研究人员旨在调查育龄期哮喘妇女使用激素避孕药与严重哮喘加重风险之间的关系。

研究人员使用了最优患者护理研究数据库,该数据库是英国基于人群的纵向匿名初级护理数据库,由17年(2000年1月1日至2016年12月31日)期间育龄期哮喘女性患者回顾性队列(16-45岁,n=83084)组成。研究人员通过阅读代码,确定了激素避孕药的使用情况、亚型和使用期限。根据欧洲呼吸学会/美国胸科学会的建议、由于哮喘急诊住院和/或口服皮质类固醇来定义严重哮喘加重。研究人员使用具有QR分解的多级混合效应Poisson回归进行分析。

随访17年,随访达456803人次每年。基线时,有34%的妇女使用激素避孕药,其中25%使用联合避孕药(雌激素/孕激素)和9%仅使用孕激素避孕药。与未使用避孕药相比,既往使用(发生率比率(IRR)为0.94,95%CI为0.92至0.97)和当前使用(IRR为0.96,95%CI为0.94至0.98)任何类型避孕药和既往使用(IRR为0.92,95%CI为0.87至0.97)和当前使用(IRR为0.93,95%CI为0.91至0.96)联合激素避孕药以及更长的使用时间(3-4年:IRR为0.94,95%CI为0.92至0.97; 5年以上:IRR为0.91,95%CI为0.89至0.93)与严重哮喘加重风险降低有关,但仅使用孕激素避孕药则不会降低严重哮喘加重风险。

由此可见,使用激素避孕药可以降低育龄妇女严重哮喘加重的风险。需要进行机制研究,以探究激素避孕药对女性哮喘临床结局影响的生物学基础。

原始出处:

Bright I Nwaru,et al.Hormonal contraception and the risk of severe asthma exacerbation: 17-year population-based cohort study.Thorax.2020.https://thorax.bmj.com/content/early/2020/10/15/thoraxjnl-2020-215540

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    2020-11-26 04754

    学习了,患有重度哮喘的女性使用避孕药要谨慎。

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    2020-12-16 潛心學習者

    使用激素避孕药可以降低育龄妇女严重哮喘加重的风险。

    0

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    2020-11-28 Baodongxu

    使用激素避孕药可以降低育龄妇女严重哮喘加重的风险。

    0

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    2020-11-27 cardio

    学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=902505, encodeId=b465902505c7, content=学习了,患有重度哮喘的女性使用避孕药要谨慎。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=2, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/accee45229794aee9359e274d0a2c508/c7705fe7d0b64e89bfeafe973c005d6e.jpg, createdBy=cdbf2000330, createdName=04754, createdTime=Thu Nov 26 16:14:56 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820426, encodeId=c2531820426b7, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Fri Dec 11 02:50:28 CST 2020, time=2020-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663685, encodeId=da36166368597, content=<a href='/topic/show?id=ec0c95810cc' target=_blank style='color:#2F92EE;'>#重度哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95810, encryptionId=ec0c95810cc, topicName=重度哮喘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f5b25663198, createdName=小几洁, createdTime=Mon Jun 07 10:50:28 CST 2021, time=2021-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908504, encodeId=9bc2908504e1, content=使用激素避孕药可以降低育龄妇女严重哮喘加重的风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=潛心學習者, createdTime=Wed Dec 16 11:14:53 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903026, encodeId=298c903026f1, content=使用激素避孕药可以降低育龄妇女严重哮喘加重的风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210315/480e12f811f44bc39b347d2521d56e86/67d0e6d503124ea685205b567af3dffd.jpg, createdBy=f9435296193, createdName=Baodongxu, createdTime=Sat Nov 28 13:36:02 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902948, encodeId=4cb89029482d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/19/d5ce32122fc3e0219d0dca8544737adf.jpg, createdBy=e0372042608, createdName=cardio, createdTime=Fri Nov 27 21:32:21 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902789, encodeId=f818902e8932, content=<a href='/topic/show?id=866f1040638c' target=_blank style='color:#2F92EE;'>#激素避孕药#</a> <a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a> 使用激素避孕药可以降低育龄妇女严重哮喘加重的风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104063, encryptionId=866f1040638c, topicName=激素避孕药), TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Fri Nov 27 12:56:47 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902521, encodeId=af1f902521fe, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/3f6f7cba9eed4938856231d858d3834e/ac814ec37c3b4165b9f968f24ce839bb.jpg, createdBy=a4424876048, createdName=1449ea27m48暂无昵称, createdTime=Thu Nov 26 16:42:07 CST 2020, time=2020-11-26, status=1, ipAttribution=)]
    2020-11-27 BJying

    #激素避孕药# #哮喘# 使用激素避孕药可以降低育龄妇女严重哮喘加重的风险。

    0

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    2020-11-26 1449ea27m48暂无昵称

    0

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