Hypertension:心血管危险因素和生活方式与高血压的关系

2020-11-04 MedSci原创 MedSci原创

这项孟德尔随机研究确定了高密度脂蛋白胆固醇、甘油三酸酯、体重指数、酒精依赖、失眠和受教育程度为高血压的因果危险因素。这意味着这些可改变的危险因素是预防高血压的重要靶标。

高血压是血管疾病和死亡率的主要危险因素。近日,心血管权威杂志Hypertension上发表了一篇研究文章,旨在明确预防高血压及其相关疾病负担的靶标,研究人员使用孟德尔随机抽样的2样本方法探究了18种心血管危险因素和生活方式与高血压之间的因果关系。

从全欧洲血统的全基因组关联研究中,研究人员选择了2型糖尿病、空腹血糖、脂质、体重指数、吸烟、饮酒和喝咖啡、体力活动、睡眠时间长短、失眠和受教育程度的遗传变异(P<5×10-8)。研究人员从2个欧洲队列中提取了与高血压相关的遗传关联:FinnGen研究(15870例病例和74345名对照者)和UK Biobank(54358例病例和408652名对照者)。研究人员采用方差反比加权法作为主要分析方法。

遗传预测的甘油三酸酯(每1 SD的合并比值比[OR]为1.17 [1.10–1.25])、体重指数(每1 SD的OR为1.42 [1.37–1.48])、酒精依赖度(OR为1.10 [1.06-1.13]) )和失眠(OR为1.17 [1.13-1.20])与高血压几率较高相关。较高的遗传预测高密度脂蛋白胆固醇(每1 SD的OR为0.88 [0.83-0.94])和教育水平(每1 SD的OR为0.56 [0.54-0.59])与高血压几率较低相关。提示性证据表明2型糖尿病、吸烟和饮酒与较高的高血压几率相关,更长的睡眠时间与较低的高血压几率相关。

这项孟德尔随机研究确定了高密度脂蛋白胆固醇、甘油三酸酯、体重指数、酒精依赖、失眠和受教育程度为高血压的因果危险因素。这意味着这些可改变的危险因素是预防高血压的重要靶标。

原始出处:

Sabine van Oort.et al.Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Hypertension A Mendelian Randomization Study.Hypertension.2020.https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.120.15761

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    2020-11-09 ms8000001754662727

    学习了

    0

  5. 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  8. 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likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Nov 04 11:13:14 CST 2020, time=2020-11-04, status=1, ipAttribution=)]
    2020-11-05 1470c28dm53暂无昵称

    学习了,非常不错

    0

  9. 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    2020-11-04 ms4211127491864495

    学习了,特别受益

    0

  10. 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likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Nov 04 11:13:14 CST 2020, time=2020-11-04, status=1, ipAttribution=)]
    2020-11-04 Jessica

    控制体重,不要喝酒,早睡早起,多读书可以预防高血压~

    0

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