J Clin Periodontol: 非手术性牙周治疗后颌骨坏死1例

2018-05-20 MedSci MedSci原创

下颌骨骨坏死与双磷酸盐相关,目前称为颌骨药物相关性骨坏死(MRONJ),考虑到除了二膦酸盐外,颌骨骨坏死还与其他抗吸收和抗血管生成药物如denosumab,舒尼替尼,贝伐单抗和ipilimumab。

下颌骨骨坏死与双磷酸盐相关,目前称为颌骨药物相关性骨坏死(MRONJ),考虑到除了二膦酸盐外,颌骨骨坏死还与其他抗吸收和抗血管生成药物如denosumab,舒尼替尼,贝伐单抗和ipilimumab。

病历如下:一位77岁患有骨质疏松症的患者,每6个月进行一次皮下注射denosumab。患者接受非手术牙周治疗后发生了MRONJ。尽管MRONJ最初被归类为该患者的I期病变,但锥形束计算机断层扫描图像证实存在显着的溶骨性病变。治疗包括给予氯己定漱口水和全身强力霉素,拔牙,截骨术和彻底手术清创坏死骨。

据我们所知,这是首例文献报道的denosumab治疗骨质疏松症患者接受非手术牙周治疗后MRONJ病例。关于牙周手术后MRONJ发生的风险以及如何预防这种并发症尚不清楚。

原始出处:

Marcio Diniz‐Freitas, et al. Denosumab‐related osteonecrosis of the jaw following non‐surgical periodontal therapy: A case report. Journal of Clinical Periodontology. 2018 May. doi:10.1111/jcpe.12882

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    2019-02-03 zll0634
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    2018-05-26 yfjms

    学习

    0

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    2018-05-25 yfjms

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1680004, encodeId=6f8f16800042d, content=<a href='/topic/show?id=f0061016322a' target=_blank style='color:#2F92EE;'>#骨坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101632, encryptionId=f0061016322a, topicName=骨坏死)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63ef27829166, createdName=zll0634, createdTime=Sun Feb 03 02:15:00 CST 2019, time=2019-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727304, encodeId=305e1e2730496, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Jul 16 02:15:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318672, encodeId=4e9d3186e27a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sat May 26 08:08:56 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318399, encodeId=09d9318399de, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri May 25 09:13:34 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318223, encodeId=265f318223f1, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Thu May 24 22:12:26 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318037, encodeId=5c1931803e6a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu May 24 06:30:38 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317721, encodeId=20eb31e721f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Wed May 23 06:29:58 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450891, encodeId=2c66145089146, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue May 22 14:15:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556642, encodeId=bda8155664272, content=<a href='/topic/show?id=0db2100694ef' target=_blank style='color:#2F92EE;'>#颌骨坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100694, encryptionId=0db2100694ef, topicName=颌骨坏死)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e2f14815893, createdName=zhmscau, createdTime=Tue May 22 14:15:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493524, encodeId=11d21493524e2, content=<a href='/topic/show?id=dc4c6e51457' target=_blank style='color:#2F92EE;'>#牙周治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67514, encryptionId=dc4c6e51457, topicName=牙周治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc259064725, createdName=cooco, createdTime=Tue May 22 14:15:00 CST 2018, time=2018-05-22, status=1, ipAttribution=)]
    2018-05-24 329523732

    不错

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1680004, encodeId=6f8f16800042d, content=<a href='/topic/show?id=f0061016322a' target=_blank style='color:#2F92EE;'>#骨坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101632, encryptionId=f0061016322a, topicName=骨坏死)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63ef27829166, createdName=zll0634, createdTime=Sun Feb 03 02:15:00 CST 2019, time=2019-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727304, encodeId=305e1e2730496, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Jul 16 02:15:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318672, encodeId=4e9d3186e27a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sat May 26 08:08:56 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318399, encodeId=09d9318399de, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri May 25 09:13:34 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318223, encodeId=265f318223f1, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Thu May 24 22:12:26 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318037, encodeId=5c1931803e6a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu May 24 06:30:38 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317721, encodeId=20eb31e721f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Wed May 23 06:29:58 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450891, encodeId=2c66145089146, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue May 22 14:15:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556642, encodeId=bda8155664272, content=<a href='/topic/show?id=0db2100694ef' target=_blank style='color:#2F92EE;'>#颌骨坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100694, encryptionId=0db2100694ef, topicName=颌骨坏死)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e2f14815893, createdName=zhmscau, createdTime=Tue May 22 14:15:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493524, encodeId=11d21493524e2, content=<a href='/topic/show?id=dc4c6e51457' target=_blank style='color:#2F92EE;'>#牙周治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67514, encryptionId=dc4c6e51457, topicName=牙周治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc259064725, createdName=cooco, createdTime=Tue May 22 14:15:00 CST 2018, time=2018-05-22, status=1, ipAttribution=)]
    2018-05-24 yfjms

    学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1680004, encodeId=6f8f16800042d, content=<a href='/topic/show?id=f0061016322a' target=_blank style='color:#2F92EE;'>#骨坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101632, encryptionId=f0061016322a, topicName=骨坏死)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63ef27829166, createdName=zll0634, createdTime=Sun Feb 03 02:15:00 CST 2019, time=2019-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727304, encodeId=305e1e2730496, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Jul 16 02:15:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318672, encodeId=4e9d3186e27a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sat May 26 08:08:56 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318399, encodeId=09d9318399de, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri May 25 09:13:34 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318223, encodeId=265f318223f1, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Thu May 24 22:12:26 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318037, encodeId=5c1931803e6a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu May 24 06:30:38 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317721, encodeId=20eb31e721f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Wed May 23 06:29:58 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450891, encodeId=2c66145089146, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue May 22 14:15:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556642, encodeId=bda8155664272, content=<a href='/topic/show?id=0db2100694ef' target=_blank style='color:#2F92EE;'>#颌骨坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100694, encryptionId=0db2100694ef, topicName=颌骨坏死)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e2f14815893, createdName=zhmscau, createdTime=Tue May 22 14:15:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493524, encodeId=11d21493524e2, content=<a href='/topic/show?id=dc4c6e51457' target=_blank style='color:#2F92EE;'>#牙周治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67514, encryptionId=dc4c6e51457, topicName=牙周治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc259064725, createdName=cooco, createdTime=Tue May 22 14:15:00 CST 2018, time=2018-05-22, status=1, ipAttribution=)]
    2018-05-23 yfjms

    学习

    0

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