J Rheumatol:系统性红斑狼疮的血压变异性和年龄相关血压模式

2019-06-25 xiangting MedSci原创

SLE中的年龄相关血压模式与一般人群不同。

尽管系统性红斑狼疮患者心血管疾病的患病率很高,但年龄、血压和血压变异性(BPV)之间的关联尚不清楚。这里研究了随诊间BPV,及其与年龄、临床、人口学特征的关联和其作为SLE患者心血管危险因素的潜在作用。

研究人员使用混合效应回归模型分析了队列中的收缩压和舒张压测量值。然后从这些模型中获得平均血压、随诊间标准差和患者间标准差的估算值。使用来自2001-2008年国家卫生统计报告中的数据,将估算的平均值与一般人群进行比较。此外,还分析了血压(平均值、方差)、患者人口学、临床特征和随后的心血管事件之间的关联。

SLE患者的平均收缩压(SBP)随年龄增长而增加,并且与一般人群相比,年轻患者的平均收缩压显著升高。系统性狼疮所有年龄段的BPV均升高。非洲裔美国人、有传统心血管危险因素的患者、疾病活动性高的患者和使用泼尼松的患者BPV显著升高。羟氯喹与BPV显著降低相关。在多因素分析中,个体舒张压变异≥9mmHg与心血管事件密切相关。

SLE中的年龄相关血压模式与一般人群不同。随诊间BPV升高受到很多疾病特异性和传统心血管因素的影响。舒张压BPV升高与SLE的心血管事件密切相关。

原始出处:

George Stojan. Blood Pressure Variability and Age-related Blood Pressure Patterns in Systemic Lupus Erythematosus. J Rheumatol. 15 June 2019.

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    2019-06-25 心介

    #血压变异性#相信未来5年是热点,不仅关心血压高与低,还要关注血压变异性才可以

    0

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