光谱抗菌药HSRx 431(TM)经测试可有效对抗寨卡病毒

2016-09-07 佚名 HSRx Biopharmaceutic

开发商HSRx Biopharmaceutical确认，其口服广谱抗病毒药物HSRx 431™可有效对抗寨卡病毒。HSRx预计在2017年初开始人体试验，并将努力加快获得美国食品药品监督管理局(U.S. Food & Drug Administration，FDA)的药品审批。

亚利桑那州图森2016年9月6日电 /美通社/ -- 用于传染病和年龄相关慢性疾病的多功能组合药物领先开发商HSRx Biopharmaceutical确认，其口服广谱抗病毒药物HSRx 431™可有效对抗寨卡病毒。HSRx预计在2017年初开始人体试验，并将努力加快获得美国食品药品监督管理局(U.S. Food & Drug Administration，FDA)的药品审批。

图标 - http://photos.prnewswire.com/prnh/20160905/404112LOGO

SRI International在其谢南多厄河谷工厂进行的筛选研究确定HSRx 431可有效对抗寨卡病毒。之前进行的体内研究表明了这款药物的安全性，以及对抗登革热和基孔肯雅热的效果。SRI International将对HSRx 431对抗寨卡病毒进行更多平行研究。同时，将完成临床协议开发和FDA注册，为寨卡病毒人体安全试验做准备。

世界卫生组织(World Health Organization)宣布没有疫苗也没有特效药的寨卡病毒主要通过埃及伊蚊传播，这种蚊子目前存在于美洲、非洲、加勒比海地区、亚洲和太平洋地区。佛罗里达州（已有数百例寨卡病毒感染）和波多黎各（已有5000例感染）特别容易受感染。美国疾病控制与预防中心(CDC)发现伊蚊传播已在约30个州被发现，美国国家过敏症和传染病研究所(NIAID)主任安东尼-弗契(Anthony Fauci)博士指出，波多黎各355万人口中25%可能会在今后一年感染寨卡病毒。

弗契博士和NIAID高级科学顾问David M. Morens博士在《新英格兰医学杂志》(New England Journal of Medicine)上写道：“在治疗方面，虫媒病毒的扩散表明‘一病一药’的手段太过局限。我们迫切需要针对全类病毒的广谱抗病毒药物。”

HSRx生物学主任、病毒学家Joshua Costin博士表示HSRx 431旨在满足上述需求。他指出：“这款药品非常及时还有另一个原因：如果有关寨卡/登革热病毒之间关联的新研究发现得到证实，那么寨卡疫苗的审批可能会更加复杂，审批也会延迟。” 弗契博士曾说过：“如果一切顺利，预计这种疫苗最早在2018年上市。”

由感染产生的抗体通常对继发感染产生免疫，但是蚊虫病毒传播方面的领先专家Scott Halstead博士最早作为一种理论报告的抗体依赖增强(ADE)则使登革热病毒能够导致后续感染，而在这种情况下抗体实际上加重了疾病。最近完成的研究表明，含有登革热抗体的人血清使寨卡病毒感染几率增加了200倍。CDC数据显示，超过三分之一的世界人口居住在有可能感染登革热病毒的地区，每年有4亿人受感染。登革热在波多黎各、拉丁美洲、东南亚、太平洋群岛、加勒比群岛地区高发，和寨卡病毒一样，预计很快在美国引起广泛感染。

HSRx首席执行官Thomas Sullivan, Jr.解释说：“我们获得HSRx 431单独使用以及与奥司他韦（达菲™）等抗病毒药物组合使用的专利权，使它成为用于包括寨卡、登革热、基孔肯雅热和流感等各种病毒感染的早期治疗和预防的首选广谱抗菌药物，而不需要确定病原体。” CDC数据显示，“在美国，每年有数百万人患流感，数十万人因流感住院、数万人死于流感。结合HSRx 431和奥司他韦将能创造一个全球范围内需要的拥有长保质期和专利寿命的口服光谱抗菌药品。”

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2016-09-09 ms7899726347904398

#抗菌#

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2016-09-09 yuandd

#寨卡病毒#

25 0
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2016-09-09 lhlxtx

#抗菌药#

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2016-09-09 12498710m14暂无昵称

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