J Nanosci Nanotechnol:改性氧化锆可增强成骨

2019-08-12 不详 网络

氧化锆(Zr)也被称为生物相容性材料,具有有利的机械性能以及低的斑块粘附性。在该研究中,我们检查了通过点击反应结合的生长和分化因子-5(GDF-5)包被的Zr作为底物的功效,以促进MC3T3-E1细胞的成骨分化。通过扫描电子显微镜(SEM)和X射线光电子能谱(XPS)表征原始和表面改性的Zr表面,使得GDF-5成功地涂覆到原始Zr表面上。涂覆在Zr表面上的GDF-5以持续的方式释放28天。GDF-

氧化锆(Zr)也被称为生物相容性材料,具有有利的机械性能以及低的斑块粘附性。在该研究中,我们检查了通过点击反应结合的生长和分化因子-5(GDF-5)包被的Zr作为底物的功效,以促进MC3T3-E1细胞的成骨分化。

通过扫描电子显微镜(SEM)和X射线光电子能谱(XPS)表征原始和表面改性的Zr表面,使得GDF-5成功地涂覆到原始Zr表面上。涂覆在Zr表面上的GDF-5以持续的方式释放28天。GDF-5包被的Zr(Zr / GDF-5)表面上的新骨形成通过体外试验证实,包括细胞增殖,碱性磷酸酶活性和钙沉积试验,实时聚合酶链反应(qPCR)试验显示osterix(OSX),runt相关转录因子2(Runx 2),COL 1(I型胶原)和骨钙蛋白(OC)的表达升高。当细胞在Zr/GDF-5上培养时,MC3T3-E1细胞的细胞增殖,碱性磷酸酶活性和钙沉积显著增强。此外,qPCR的结果显示,当细胞在Zr/GDF-5上培养时,与成骨分化相关的基因被上调。

综上所述,该研究结果表明,Zr/GDF-5可用作增强成骨分化的材料。

原始出处:

Yoon SJ, Yang DH, et al., In Vitro Osteogenic Differentiation Enhanced by Zirconia Coated with Nano-Layered Growth and Differentiation Factor-5. J Nanosci Nanotechnol. 2016 Jan;16(1):280-6.

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