JAMA Surg:胃腺癌全胃切除术后住院费用与并发症的关系

2017-06-30 zhangfan MedSci原创

根治性全胃切除术后重度并发症患者术后费用增加了3倍,大部分的额外费用与并发症的治疗有关。术后并发症预防有助于节约医疗成本

术后并发症与术后住院费用增加有关,近日研究人员就胃腺癌全胃切除术后并发症与住院费用之间的关系开展研究。

研究人员对2009-12年间,国家癌症研究所数据库的根治性胃癌全胃切除术患者资料进行回顾性前瞻分析。主要终点是术后90天标准化费用。医疗保险比例美元(MP$)的成本差异可以用于评估医疗机构因手术并发症的类型和程度导致的医疗保险费用差异。

2009-12年间,共进行了120例根治性全胃切除胃腺癌(I期至III),其中79名为男性,平均年龄64岁。接受简单的全胃切除术的51(42.5%)患者平均花费为MP $12330,主要费用为外科手术花费(MP $6830),但存在重度并发症的34名患者(28.3%)的平均花费为MP $37700,重度并发症患者术后护理费用较高(平均花费MP $8970),但占总成本的比例较小(24%),其他的主要花费包括食宿(MP $11940)、检查会诊(MP $3530)以及ICU护理(MP $7770)

研究发现,根治性全胃切除术后重度并发症患者术后费用增加了3倍,大部分的额外费用与并发症的治疗有关。术后并发症预防有助于节约医疗成本。

原始出处:

Luke V. Selby et al. Association of Hospital Costs With Complications Following Total Gastrectomy for Gastric Adenocarcinoma. JAMA Surg. June 28 2017.

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    2018-04-10 丁鹏鹏
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1876902, encodeId=3b2218e69023e, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Tue Apr 10 21:28:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757806, encodeId=df271e578062b, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Tue Apr 10 04:28:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972259, encodeId=1a8719e2259bb, content=<a href='/topic/show?id=6c32264625a' target=_blank style='color:#2F92EE;'>#住院费用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26462, encryptionId=6c32264625a, topicName=住院费用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Fri Oct 13 10:28:00 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305920, encodeId=a27f1305920bf, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Sun Jul 02 01:28:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518562, encodeId=4c691518562a7, content=<a href='/topic/show?id=324183166ad' target=_blank style='color:#2F92EE;'>#胃切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83166, encryptionId=324183166ad, topicName=胃切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3cc11160823, createdName=bshuang, createdTime=Sun Jul 02 01:28:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217429, encodeId=89bc21e42927, content=这是肯定的,无并发症就无需再花费喽。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM5FldxKiaxE2UHqibuNCmdiadsVa9PmHEnDcTaVuuNX8trqZU0sRzia8XOFHmt2VbuxQTMad8AxIibyr5A5ofwenn0rJkLCw7JCUN1g/0, createdBy=b41d2067240, createdName=136****6619, createdTime=Sat Jul 01 14:31:41 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217094, encodeId=f43821e09411, content=是并发症的发生导致费用增加,还是增加的住院费用导致产生了更多的并发症?, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2fd22000731, createdName=风一样的女孩, createdTime=Fri Jun 30 13:17:54 CST 2017, time=2017-06-30, status=1, ipAttribution=)]
    2017-07-02 bshuang
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    2017-07-01 136****6619

    这是肯定的,无并发症就无需再花费喽。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1876902, encodeId=3b2218e69023e, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Tue Apr 10 21:28:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757806, encodeId=df271e578062b, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Tue Apr 10 04:28:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972259, encodeId=1a8719e2259bb, content=<a href='/topic/show?id=6c32264625a' target=_blank style='color:#2F92EE;'>#住院费用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26462, encryptionId=6c32264625a, topicName=住院费用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Fri Oct 13 10:28:00 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305920, encodeId=a27f1305920bf, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Sun Jul 02 01:28:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518562, encodeId=4c691518562a7, content=<a href='/topic/show?id=324183166ad' target=_blank style='color:#2F92EE;'>#胃切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83166, encryptionId=324183166ad, topicName=胃切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3cc11160823, createdName=bshuang, createdTime=Sun Jul 02 01:28:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217429, encodeId=89bc21e42927, content=这是肯定的,无并发症就无需再花费喽。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM5FldxKiaxE2UHqibuNCmdiadsVa9PmHEnDcTaVuuNX8trqZU0sRzia8XOFHmt2VbuxQTMad8AxIibyr5A5ofwenn0rJkLCw7JCUN1g/0, createdBy=b41d2067240, createdName=136****6619, createdTime=Sat Jul 01 14:31:41 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217094, encodeId=f43821e09411, content=是并发症的发生导致费用增加,还是增加的住院费用导致产生了更多的并发症?, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2fd22000731, createdName=风一样的女孩, createdTime=Fri Jun 30 13:17:54 CST 2017, time=2017-06-30, status=1, ipAttribution=)]
    2017-06-30 风一样的女孩

    是并发症的发生导致费用增加,还是增加的住院费用导致产生了更多的并发症?

    0

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胃癌是世界第三大癌症。在中国,每年有超过四十万病人受到胃癌的危害。对于局部晚期胃癌患者来说,目前手术彻底切除仍然是现有治疗方案的基石。胃癌具有起病隐匿、早期常因无明显症状而漏诊、易转移与复发和预后差等特点。胃癌的病因迄今尚未完全阐明。通过对胃癌发病的地理分布以及与移民关系的研究,一般认为外界环境和饮食因素与胃癌的发生关系最为密切,人体还有些利于胃癌发生的条件,也是不容忽视的。这里梅斯小编整理近

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据报道,人甲酰肽受体2(FPR2)是G蛋白偶联受体的经典化学引诱物受体,并且与一些癌症的侵袭和转移相关,但FPR2在胃癌(GC)中的作用尚未阐明。在本研究中,我们发现GC中FPR2表达水平与入侵深度,淋巴结转移呈正相关,与患者总生存率呈负相关。

JCO:Her-2阳性胃或胃食管结合部腺癌:标准治疗vs高剂量的曲妥珠单抗联合化疗(IIIb期多中心随机研究)

发表在6月的JCO上的一篇研究中,来自美中韩三国的研究人员在一线治疗的人表皮生长因子受体-2阳性的转移性胃或胃食管结合部腺癌患者中对标准治疗(SoC)曲妥珠单抗联合化疗vs高剂量(HD)曲妥珠单抗联合化疗进行对比后,探讨高剂量曲妥珠单抗是否升高曲妥珠单抗的血清谷浓度(Ctrough)水平,或是否会提高总生存率(OS)。来自东部肿瘤协作组的(Her-2)阳性,且之前为接受过胃切除术及有≥2个转移灶的

Gut:IRTKS与胃癌进展和患者生存时间相关

IRTKS是抑癌基因p53的新型调节因子。但是它在胃癌病程中的作用还不清楚。来自上海交通大学的课题组近日在肠道杂志发文,利用免疫组化的方式,检测了527个人类胃癌标本中的IRTKS水平。他们建立了IRTK3缺陷和p53缺陷的小鼠模型,观察小鼠的生存时间。小鼠胚胎成纤维细胞(MEF)也被分离出来,观察体内致瘤性。免疫共沉淀被用来检测p53,MDM2和IRTKS之间的相互作用,以及p53的泛素化。