AIDS: 艾滋病感染可诱发肺癌发病率

2015-04-22 范伟译 MedSci原创

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目的: 确定艾滋病毒感染和未感染的男性和女性中肺癌发病率和存活时间。

设计: 在美国的艾滋病毒感染的两个纵向研究。

方法: 对来自妇女跨部门艾滋病毒研究(WIHS)的2549名女性和多中心艾滋病群组研究(MACS)的4274名男性的数据进行了分析，所有的患者都有吸烟历史。肺癌发病率和发生率比率采用泊松回归分析进行计算。生存时间采用Kaplan-Meier和Cox proportional-hazard分析进行评估。

结果: 在研究随访中，37名女性和23名男性患有肺癌(46个艾滋病毒感染的和14个未感染的)。在多变量分析中，更高比例的肺癌发病率独立预测因素有年龄，较低的教育程度，10年或者更长的烟龄，先前有诊断的艾滋病肺炎(vs 未感染艾滋病的女性)。在调整的Cox模型中，允许每组不同的风险函数，注射吸毒的历史与较短生存期相关，2001年后诊断为肺癌与较长的生存期相关。调整的Cox模型局限于艾滋病毒感染的受试者，最低点CD4淋巴细胞数量低于200与较短的存活期相关。

结论: 我们的数据表明，肺损伤和炎症与艾滋病毒感染有关，可能诱发肺癌的风险增加。鼓励和帮助年轻艾滋病毒感染的吸烟者停止吸烟和维持戒烟，对于这个人群肺癌负担的减少是必须的。

原始出处：

Hessol NA1, Martínez-Maza O, Levine AM, Morris A, Margolick JB, Cohen MH, Jacobson LP, Seaberg EC. Lung cancer incidence and survival among HIV-infected and uninfected women and men. AIDS. 2015 Apr 17.

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2016-04-05 chenhongpeng

#癌发病率#

31 0
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2015-09-22 lifestar

#发病率#

36 0
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2015-12-09 12498636m49(暂无昵称)

#癌发病#

28 0
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2015-08-13 jjjiang0199

#艾滋病感染#

36 0
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2015-06-07 wjywjy

#AID#

34 0
[GetPortalCommentsPageByObjectIdResponse(id=2079236, encodeId=cfc220e9236a2, content=<a href='/topic/show?id=659ce1280ee' target=_blank style='color:#2F92EE;'>#癌发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71280, encryptionId=659ce1280ee, topicName=癌发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Tue Apr 05 10:00:00 CST 2016, time=2016-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823232, encodeId=4a881823232d0, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Tue Sep 22 00:00:00 CST 2015, time=2015-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799803, encodeId=b2701e998033a, content=<a href='/topic/show?id=9e3fe127909' target=_blank style='color:#2F92EE;'>#癌发病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71279, encryptionId=9e3fe127909, topicName=癌发病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2c92500045, createdName=12498636m49(暂无昵称), createdTime=Wed Dec 09 10:00:00 CST 2015, time=2015-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811062, encodeId=3e1f1811062d4, content=<a href='/topic/show?id=bf6b8680136' target=_blank style='color:#2F92EE;'>#艾滋病感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86801, encryptionId=bf6b8680136, topicName=艾滋病感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Thu Aug 13 19:00:00 CST 2015, time=2015-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033819, encodeId=ee3e20338191f, content=<a href='/topic/show?id=852b216824' target=_blank style='color:#2F92EE;'>#AID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2168, encryptionId=852b216824, topicName=AID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Sun Jun 07 09:00:00 CST 2015, time=2015-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365611, encodeId=f42d136561179, content=<a href='/topic/show?id=41fa21e036' target=_blank style='color:#2F92EE;'>#AIDS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2170, encryptionId=41fa21e036, topicName=AIDS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbcc223, createdName=cooco, createdTime=Fri Apr 24 03:00:00 CST 2015, time=2015-04-24, status=1, ipAttribution=)]
2015-04-24 cooco

#AIDS#

28 0

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