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Bone Res：骨髓间充质干细胞中的RANKL信号传导负调节成骨细胞骨形成

2019-02-09 MedSci MedSci原创

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RANKL信号传导对破骨细胞生成至关重要，但是其在成骨细胞分化和骨形成中的作用尚不清楚。 本研究中，我们发现RANK在骨髓间充质干细胞（BMSCs）的早期阶段在小鼠和人的成骨分化期间表达并且迅速减少。RANKL信号通过促进β-连环蛋白降解和抑制其合成来抑制成骨。 相反，RANKL信号传导对BMSCs的脂肪形成没有明显影响。有趣的是，在具有Prx1-Cre小鼠的BMSCs中有条件地敲除rank导致更

RANKL信号传导对破骨细胞生成至关重要，但是其在成骨细胞分化和骨形成中的作用尚不清楚。

本研究中，我们发现RANK在骨髓间充质干细胞（BMSCs）的早期阶段在小鼠和人的成骨分化期间表达并且迅速减少。RANKL信号通过促进β-连环蛋白降解和抑制其合成来抑制成骨。 相反，RANKL信号传导对BMSCs的脂肪形成没有明显影响。有趣的是，在具有Prx1-Cre小鼠的BMSCs中有条件地敲除rank导致更高的骨量和增加的骨小梁形成，而不依赖于破骨细胞。此外，rank flox/flox：Prx1-Cre小鼠显示出对卵巢切除-（OVX）诱导的骨丢失的抗性。

因此，我们的结果揭示RANKL信号通过抑制BMSCs的成骨分化和促进破骨细胞生成来调节破骨细胞和成骨细胞。

原始出处：

Chen X, Zhi X, et al., RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation. Bone Res. 2018 Nov 27;6:34. doi: 10.1038/s41413-018-0035-6. eCollection 2018.

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    2019-07-31 apoenzyme

    #Bone#

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    2019-03-13 h.y200607_23674418

    #间充质干细#

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360262, encodeId=3cf936026278, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Feb 09 14:56:49 CST 2019, time=2019-02-09, status=1, ipAttribution=)]
    2019-03-04 ying_wu

    #骨髓间充质干细胞#

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360262, encodeId=3cf936026278, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Feb 09 14:56:49 CST 2019, time=2019-02-09, status=1, ipAttribution=)]
    2019-02-11 zwjnj2

    学习学习努力学习

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360262, encodeId=3cf936026278, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Feb 09 14:56:49 CST 2019, time=2019-02-09, status=1, ipAttribution=)]
    2019-02-11 yjs木玉

    好好好好好好

    0

  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360262, encodeId=3cf936026278, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Feb 09 14:56:49 CST 2019, time=2019-02-09, status=1, ipAttribution=)]
    2019-02-10 qingfengqishi5

    学习了，学习了

    0

  7. 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href='/topic/show?id=1a2b151156f' target=_blank style='color:#2F92EE;'>#RANKL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15115, encryptionId=1a2b151156f, topicName=RANKL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Feb 10 17:53:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495138, encodeId=5fc2149513873, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Sun Feb 10 17:53:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360262, encodeId=3cf936026278, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Feb 09 14:56:49 CST 2019, time=2019-02-09, status=1, ipAttribution=)]
    2019-02-10 zhaojie88

    #成骨#

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Mon Feb 11 19:16:01 CST 2019, time=2019-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360358, encodeId=7bce36035851, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Feb 11 05:24:43 CST 2019, time=2019-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360337, encodeId=309136033e70, content=学习了，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Sun Feb 10 18:00:42 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352023, encodeId=080f135202373, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Feb 10 17:53:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465948, encodeId=05e4146594896, content=<a href='/topic/show?id=1a2b151156f' target=_blank style='color:#2F92EE;'>#RANKL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15115, encryptionId=1a2b151156f, topicName=RANKL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Feb 10 17:53:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495138, encodeId=5fc2149513873, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Sun Feb 10 17:53:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360262, encodeId=3cf936026278, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Feb 09 14:56:49 CST 2019, time=2019-02-09, status=1, ipAttribution=)]
    2019-02-10 智智灵药

    #RANKL#

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Mon Feb 11 19:16:01 CST 2019, time=2019-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360358, encodeId=7bce36035851, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Feb 11 05:24:43 CST 2019, time=2019-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360337, encodeId=309136033e70, content=学习了，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Sun Feb 10 18:00:42 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352023, encodeId=080f135202373, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Feb 10 17:53:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465948, encodeId=05e4146594896, content=<a href='/topic/show?id=1a2b151156f' target=_blank style='color:#2F92EE;'>#RANKL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15115, encryptionId=1a2b151156f, topicName=RANKL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Feb 10 17:53:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495138, encodeId=5fc2149513873, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Sun Feb 10 17:53:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360262, encodeId=3cf936026278, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Feb 09 14:56:49 CST 2019, time=2019-02-09, status=1, ipAttribution=)]
    2019-02-10 jj000004

    #骨细胞#

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360262, encodeId=3cf936026278, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Feb 09 14:56:49 CST 2019, time=2019-02-09, status=1, ipAttribution=)]
    2019-02-09 明月清辉

    谢谢分享，学习了

    0

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