Lasers Med Sci:低能量和低密度的二氧化碳点阵激光可有效进行面部光子嫩肤

2022-04-05 MedSci原创 MedSci原创

低能量和低密度的二氧化碳点阵激光是面部光子嫩肤的一个安全和有效的选择。

高功率CO2激光器被认为是光嫩肤的黄金标准,也适用于治疗萎缩性和肥厚性疤痕和妊娠纹,但是并发症也较多。本研究旨在对低能量和低密度的二氧化碳点阵激光单次治疗后的光子嫩肤效果进行临床和组织学分析。从组织学上分析I型和III型胶原纤维、弹性纤维和表皮厚度在D84的定量变化,同时对同期眼周皱纹的数量、长度、厚度和深度进行临床评估。

该项开放性、前瞻性、干预性的研究共纳入40名健康女性,年龄在35至65岁之间。随机选择26名参与者进行D0和D84活检。在脸上做了一次点阵式二氧化碳激光,使用800-µm的尖端,5%的密度,10毫焦耳的能量,单通量。在D0、D42和D84,对眼周皱纹的数量、长度、深度和厚度进行了临床比较分析。组织学分析方面,在D0和D84,对I型和III型胶原纤维、弹性纤维和表皮厚度做了比较性的定量评估。

结果显示,激光治疗以后,眼周皱纹的数量(- 32.17%;p < 0.0001)、厚度(- 33%;p < 0.0001)、长度(- 35.84%;p < 0.0001)和深度(- 32.46%;p < 0.0001)都有明显的临床改善。在D84观察到III型胶原纤维的数量明显增加(+60.67%;p = 0.0013)。但是,I型胶原纤维增加不明显(+ 8.31%;p = 0.3820),弹性纤维的量减少(- 12.4%;p = 0.0585)。表皮厚度有显著变化的趋势(p = 0.05553)。

综上所述,该研究结果表明,低能量和低密度的二氧化碳点阵激光是面部光子嫩肤的一个安全和有效的选择。

 

原始出处:

Juliana Merheb Jordão, et al., Low-fluence and low-density CO2 laser: histological analysis of collagen fiber changes in skin and its clinical repercussions in photorejuvenation. Lasers Med Sci. 2022 Mar;37(2):905-911. doi: 10.1007/s10103-021-03330-0.  

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    2022-08-06 anminleiryan
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    2022-04-06 oliver169
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