GUT:酒精性和非酒精性脂肪肝都是冠状动脉钙化的风险因素

2018-12-02 MedSci MedSci原创

最近有证据表明,酒精性脂肪性肝病(AFLD)和非酒精性脂肪性肝病(NAFLD)可能会对心血管死亡风险产生不同影响。为了研究AFLD或NAFLD引起的早期肝病是否对早期冠状动脉粥样硬化的风险有相似或不相似的影响,研究人员研究了AFLD与NAFLD和冠状动脉钙(CAC)之间的关系。

背景及目的
最近有证据表明,酒精性脂肪性肝病(AFLD)和非酒精性脂肪性肝病(NAFLD)可能会对血管死亡风险产生不同影响。为了研究AFLD或NAFLD引起的早期肝病是否对早期冠状动脉粥样硬化的风险有相似或不相似的影响,研究人员研究了AFLD与NAFLD和冠状动脉钙(CAC)之间的关系。

方法
研究人员对参加健康检查的105328名成年人进行了横断面研究。使用CT进行CAC评分评估,将每日酒精摄入记录为克/天和通过超声记录肝脏脂肪含量。Logistic回归模型用于计算流行CAC的95%CI的OR。

结果
NAFLD和AFLD均与CAC评分呈正相关关系。NAFLD和AFLD与CAC>0的OR值分别为1.10(95%CI 1.05-1.16)和1.20 (95%CI 1.11-1.30)。NAFLD和AFLD与CAC评分在非肥胖和肥胖个体中有着相似的关系(p = 0.088)。在调整胰岛素抵抗和高敏C反应蛋白的稳态模型评估后,脂肪肝疾病与CAC评分之间的关联仍然具有统计学意义。

结论
在大样本人群中得到证实即NAFLD和AFLD引起的早期肝病都与冠状动脉钙化的存在显着相关。

原始出处:

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