JAMA Oncol:他汀类药物对前列腺癌筛查的影响

2021-11-29 Nebula MedSci原创

他汀类药物的使用不会损害基于 PSA 的前列腺癌筛查获益

前列腺癌的前列腺特异性抗原 (PSA) 筛查导致前列腺癌死亡率略有下降,但同时也导致低风险肿瘤遭受过度诊断。前列腺特异性抗原水平受降胆固醇他汀类药物的使用影响,但他汀类药物的使用与 PSA 筛查性能的相关性尚不清楚。

本研究旨在探究他汀类药物使用是否与基于 PSA 的随机前列腺癌筛查干预的结果相关。

这是一项基于人群的随机临床试验队列的事后亚组分析,使用了基于人群的芬兰前列腺癌筛查随机研究的数据,1996年3月1日至1999年12月31日期间,该随机研究将男性随机分至PSA筛查或常规医疗组,随访至2015年12月31日。主要终点是前列腺癌的发生率。

前列腺癌的累积发生率和死亡率

共纳入了78606位有他汀类药物购买数据的男性(中位年龄 59岁,范围 55-67岁)。虽然 PSA 筛查与他汀类药物-非使用者的前列腺癌发病率增加有关(筛查组 vs 对照组:11.2 vs 8.6/1000人·年;发生率比[RR] 1.31,95% CI 1.24-1.38),但在他汀类药物-使用者中未观察到类似的发病率增加(6.9 vs 5.9/1000人·年; RR 1.02,95% CI 0.95-1.10; P<0.001)。他汀类药物使用者的低风险肿瘤(格里森评分 6分)和局限性肿瘤的发生率较低,但两组间格里森评分为8-10分的肿瘤检出率相似。无论是否使用他汀类药物,筛查都与转移性肿瘤较低的发生率相关。

根据他汀类药物使用情况分层,筛查与不同预后的相关性

综上,在这项基于人群的随机临床试验队列的事后亚组分析中,他汀类药物-使用者的 PSA 筛查与晚期前列腺癌的发病率降低有关,在他汀类药物-非使用者中亦是如此;但与他汀类药物-非使用者相比,他汀类药物-使用者的低级别局限性肿瘤的检出增加较少。总之,研究结果表明,他汀类药物的使用不会损害基于 PSA 的筛查的获益。

原始出处:

Vettenranta A, Murtola TJ, Raitanen J, et al. Outcomes of Screening for Prostate Cancer Among Men Who Use Statins. JAMA Oncol. Published online November 24, 2021. doi:10.1001/jamaoncol.2021.5672

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1866387, encodeId=3579186638e5b, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat May 28 17:33:01 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634849, encodeId=312e1634849ed, content=<a href='/topic/show?id=9e7e3254ef1' target=_blank style='color:#2F92EE;'>#前列腺癌筛查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32547, encryptionId=9e7e3254ef1, topicName=前列腺癌筛查)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ddf122300708, createdName=124984e7m90暂无昵称, createdTime=Sun Aug 21 14:33:01 CST 2022, time=2022-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044629, encodeId=6863204462994, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed Feb 23 23:33:01 CST 2022, time=2022-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075386, encodeId=972410e53863c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09985652468, createdName=ms6000000145764456, createdTime=Tue Nov 30 10:54:22 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075338, encodeId=5bdc10e53387c, content=前列腺癌的前列腺特异性抗原 (PSA) 筛查导致, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Nov 30 09:07:09 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075318, encodeId=349d10e53188d, content=学习了,以前还没怎么关注这一块呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/fb49ede2bc714e14abb1a1024e3f6969/ca936d1263ab48ffba726dafc70bcdb2.jpg, createdBy=92c35391508, createdName=冷小落, createdTime=Tue Nov 30 08:03:55 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075250, encodeId=0acf10e525065, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Nov 29 23:53:52 CST 2021, time=2021-11-29, status=1, ipAttribution=)]
    2022-05-28 minlingfeng
  2. [GetPortalCommentsPageByObjectIdResponse(id=1866387, encodeId=3579186638e5b, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat May 28 17:33:01 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634849, encodeId=312e1634849ed, content=<a href='/topic/show?id=9e7e3254ef1' target=_blank style='color:#2F92EE;'>#前列腺癌筛查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32547, encryptionId=9e7e3254ef1, topicName=前列腺癌筛查)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ddf122300708, createdName=124984e7m90暂无昵称, createdTime=Sun Aug 21 14:33:01 CST 2022, time=2022-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044629, encodeId=6863204462994, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed Feb 23 23:33:01 CST 2022, time=2022-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075386, encodeId=972410e53863c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09985652468, createdName=ms6000000145764456, createdTime=Tue Nov 30 10:54:22 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075338, encodeId=5bdc10e53387c, content=前列腺癌的前列腺特异性抗原 (PSA) 筛查导致, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Nov 30 09:07:09 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075318, encodeId=349d10e53188d, content=学习了,以前还没怎么关注这一块呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/fb49ede2bc714e14abb1a1024e3f6969/ca936d1263ab48ffba726dafc70bcdb2.jpg, createdBy=92c35391508, createdName=冷小落, createdTime=Tue Nov 30 08:03:55 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075250, encodeId=0acf10e525065, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Nov 29 23:53:52 CST 2021, time=2021-11-29, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1866387, encodeId=3579186638e5b, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat May 28 17:33:01 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634849, encodeId=312e1634849ed, content=<a href='/topic/show?id=9e7e3254ef1' target=_blank style='color:#2F92EE;'>#前列腺癌筛查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32547, encryptionId=9e7e3254ef1, topicName=前列腺癌筛查)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ddf122300708, createdName=124984e7m90暂无昵称, createdTime=Sun Aug 21 14:33:01 CST 2022, time=2022-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044629, encodeId=6863204462994, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed Feb 23 23:33:01 CST 2022, time=2022-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075386, encodeId=972410e53863c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09985652468, createdName=ms6000000145764456, createdTime=Tue Nov 30 10:54:22 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075338, encodeId=5bdc10e53387c, content=前列腺癌的前列腺特异性抗原 (PSA) 筛查导致, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Nov 30 09:07:09 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075318, encodeId=349d10e53188d, content=学习了,以前还没怎么关注这一块呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/fb49ede2bc714e14abb1a1024e3f6969/ca936d1263ab48ffba726dafc70bcdb2.jpg, createdBy=92c35391508, createdName=冷小落, createdTime=Tue Nov 30 08:03:55 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075250, encodeId=0acf10e525065, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Nov 29 23:53:52 CST 2021, time=2021-11-29, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1866387, encodeId=3579186638e5b, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat May 28 17:33:01 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634849, encodeId=312e1634849ed, content=<a href='/topic/show?id=9e7e3254ef1' target=_blank style='color:#2F92EE;'>#前列腺癌筛查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32547, encryptionId=9e7e3254ef1, topicName=前列腺癌筛查)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ddf122300708, createdName=124984e7m90暂无昵称, createdTime=Sun Aug 21 14:33:01 CST 2022, time=2022-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044629, encodeId=6863204462994, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed Feb 23 23:33:01 CST 2022, time=2022-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075386, encodeId=972410e53863c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09985652468, createdName=ms6000000145764456, createdTime=Tue Nov 30 10:54:22 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075338, encodeId=5bdc10e53387c, content=前列腺癌的前列腺特异性抗原 (PSA) 筛查导致, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Nov 30 09:07:09 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075318, encodeId=349d10e53188d, content=学习了,以前还没怎么关注这一块呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/fb49ede2bc714e14abb1a1024e3f6969/ca936d1263ab48ffba726dafc70bcdb2.jpg, createdBy=92c35391508, createdName=冷小落, createdTime=Tue Nov 30 08:03:55 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075250, encodeId=0acf10e525065, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Nov 29 23:53:52 CST 2021, time=2021-11-29, status=1, ipAttribution=)]
    2021-11-30 ms6000000145764456

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1866387, encodeId=3579186638e5b, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat May 28 17:33:01 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634849, encodeId=312e1634849ed, content=<a href='/topic/show?id=9e7e3254ef1' target=_blank style='color:#2F92EE;'>#前列腺癌筛查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32547, encryptionId=9e7e3254ef1, topicName=前列腺癌筛查)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ddf122300708, createdName=124984e7m90暂无昵称, createdTime=Sun Aug 21 14:33:01 CST 2022, time=2022-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044629, encodeId=6863204462994, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed Feb 23 23:33:01 CST 2022, time=2022-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075386, encodeId=972410e53863c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09985652468, createdName=ms6000000145764456, createdTime=Tue Nov 30 10:54:22 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075338, encodeId=5bdc10e53387c, content=前列腺癌的前列腺特异性抗原 (PSA) 筛查导致, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Nov 30 09:07:09 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075318, encodeId=349d10e53188d, content=学习了,以前还没怎么关注这一块呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/fb49ede2bc714e14abb1a1024e3f6969/ca936d1263ab48ffba726dafc70bcdb2.jpg, createdBy=92c35391508, createdName=冷小落, createdTime=Tue Nov 30 08:03:55 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075250, encodeId=0acf10e525065, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Nov 29 23:53:52 CST 2021, time=2021-11-29, status=1, ipAttribution=)]
    2021-11-30 查查佳佳

    前列腺癌的前列腺特异性抗原 (PSA) 筛查导致

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1866387, encodeId=3579186638e5b, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat May 28 17:33:01 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634849, encodeId=312e1634849ed, content=<a href='/topic/show?id=9e7e3254ef1' target=_blank style='color:#2F92EE;'>#前列腺癌筛查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32547, encryptionId=9e7e3254ef1, topicName=前列腺癌筛查)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ddf122300708, createdName=124984e7m90暂无昵称, createdTime=Sun Aug 21 14:33:01 CST 2022, time=2022-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044629, encodeId=6863204462994, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed Feb 23 23:33:01 CST 2022, time=2022-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075386, encodeId=972410e53863c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09985652468, createdName=ms6000000145764456, createdTime=Tue Nov 30 10:54:22 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075338, encodeId=5bdc10e53387c, content=前列腺癌的前列腺特异性抗原 (PSA) 筛查导致, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Nov 30 09:07:09 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075318, encodeId=349d10e53188d, content=学习了,以前还没怎么关注这一块呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/fb49ede2bc714e14abb1a1024e3f6969/ca936d1263ab48ffba726dafc70bcdb2.jpg, createdBy=92c35391508, createdName=冷小落, createdTime=Tue Nov 30 08:03:55 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075250, encodeId=0acf10e525065, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Nov 29 23:53:52 CST 2021, time=2021-11-29, status=1, ipAttribution=)]
    2021-11-30 冷小落

    学习了,以前还没怎么关注这一块呢

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1866387, encodeId=3579186638e5b, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat May 28 17:33:01 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634849, encodeId=312e1634849ed, content=<a href='/topic/show?id=9e7e3254ef1' target=_blank style='color:#2F92EE;'>#前列腺癌筛查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32547, encryptionId=9e7e3254ef1, topicName=前列腺癌筛查)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ddf122300708, createdName=124984e7m90暂无昵称, createdTime=Sun Aug 21 14:33:01 CST 2022, time=2022-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044629, encodeId=6863204462994, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed Feb 23 23:33:01 CST 2022, time=2022-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075386, encodeId=972410e53863c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09985652468, createdName=ms6000000145764456, createdTime=Tue Nov 30 10:54:22 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075338, encodeId=5bdc10e53387c, content=前列腺癌的前列腺特异性抗原 (PSA) 筛查导致, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Nov 30 09:07:09 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075318, encodeId=349d10e53188d, content=学习了,以前还没怎么关注这一块呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/fb49ede2bc714e14abb1a1024e3f6969/ca936d1263ab48ffba726dafc70bcdb2.jpg, createdBy=92c35391508, createdName=冷小落, createdTime=Tue Nov 30 08:03:55 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1075250, encodeId=0acf10e525065, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Nov 29 23:53:52 CST 2021, time=2021-11-29, status=1, ipAttribution=)]
    2021-11-29 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

相关资讯

低PSA前列腺癌不好筛还易漏?试试MRI靶向活检!

Scientifc Reports:MRI靶向前列腺活检在低前列腺特异性抗原水平的男性中检测临床显著前列腺癌的有效性。

Prostate:体外放射治疗是否影响前列腺癌老年患者的生存率?

调查了体外放射治疗是否影响前列腺癌老年患者的生存率。

Prostate:11C-choline PET/CT在转移去势抗性前列腺癌患者中的预后价值如何?

评估了11C-胆碱正电子发射断层扫描/计算机断层扫描(PET/CT)在接受多西他赛化疗的转移去势抵抗性前列腺癌(mCRPC)患者中的预后效用。

J Urol:活检与根治性前列腺切除术之间的时间间隔影响治疗结果么?

调查了活检与根治性前列腺切除术之间的时间间隔对治疗结果的影响情况。

Eur Urol:转移去势抵抗性前列腺癌中,激素治疗与化疗获益的预测性基因组生物标志物调查

新的激素疗法(NHTs),如阿比特龙和恩扎鲁胺,以及基于紫杉类药物的化疗,是治疗转移去势抵抗性前列腺癌(mCRPC)的常用系统疗法。

JCO:采用多西他赛 vs 阿比特龙治疗的前列腺癌患者的生活质量

患者报告的生活质量可指导选择哪种联合疗法