J Gastroenterol Hepatol:胆结石患者小肠细菌过度生长的特点

2018-08-27 MedSci MedSci原创

小肠细菌过度生长在胆结石患者中很常见。特别是CH4或混合型,SIBO似乎普遍存在,使肠道症状加重。

研究背景和目的:小肠细菌过度生长(SIBO)可能在胆结石疾病中很常见,包括胆囊切除术和胆结石。本研究旨在探讨胆结石患者SIBO的患病率及特点。

研究方法:该项前瞻性研究评估了265例胆结石(200例胆结石和65例胆囊切除)和39例健康对照者的数据。分析实验室数据、腹部超声及葡萄糖呼吸试验(GBT)以及进行肠道症状问卷。

研究结果:胆结石患者葡萄糖呼吸试验阳性率(+)(36.6%)明显高于对照组(20.5%)患者。胆结石组GBT+(40.5%)明显高于对照组或胆囊切除术组(24.6%)。胆结石患者中,GBT (H2)+、(CH4)+、(混合)+组(56例[28.0%]、11例[5.5%]、14例[7.00%])的发生率较高。胆囊疾病与脂肪肝、代谢综合征和SIBO等独立相关。在97例GBT+患者中,分别有70例(72.1%)、12例(12.4%)和15例(15.5%)属于GBT (H2)+、(CH4)+和(混合)+组。与胆囊切除术组相比,胆结石组与GBT (CH4)+或GBT(混合)+显著相关。GBT(混合)+组在硬卧和急症倾向方面的症状得分高于GBT-组或GBT (H2)+组相比GBT-组,有硬卧和疏松倾向方面的趋势。胆结石是胆结石疾病患者SIBO的唯一独立因素。

研究结论:小肠细菌过度生长在胆结石患者中很常见。特别是CH4或混合型,SIBO似乎普遍存在,使肠道症状加重。

原始出处

Kim DB, Paik CN, Song DS, et al. The characteristics of small intestinal bacterial overgrowth in patients with gallstone diseases. J Gastroenterol Hepatol, 2018, 33(8), 1477-1484.

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    2018-12-15 许安
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    2018-08-29 gwc384
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    2018-08-28 131****1460

    学习了受益匪浅

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