Nanoscale:石墨烯负载姜黄素可有效对抗RSV感染

2017-12-01 MedSci MedSci原创

病毒引起的疾病仍然是一个全球性的负担。呼吸道合胞病毒(RSV)是婴幼儿下呼吸道疾病的主要病毒性病原体,与严重的肺部疾病的发生有关。在此基础上,我们开发了一种具有高效抗病毒活性的β-环糊精(CD)功能化氧化石墨烯(GO)复合材料,能有效地负载姜黄素。RSV是一种负性单链RNA病毒,以此为模型病毒研究多功能GO的抗病毒活性。经组织培养感染剂量试验和免疫荧光试验证实,负载姜黄素的功能化GO对RSV感染具

病毒引起的疾病仍然是一个全球性的负担。呼吸道合胞病毒(RSV)是婴幼儿下呼吸道疾病的主要病毒性病原体,与严重的肺部疾病的发生有关。

在此基础上,我们开发了一种具有高效抗病毒活性的β-环糊精(CD)功能化氧化石墨烯(GO)复合材料,能有效地负载姜黄素。RSV是一种负性单链RNA病毒,以此为模型病毒研究多功能GO的抗病毒活性。

经组织培养感染剂量试验和免疫荧光试验证实,负载姜黄素的功能化GO对RSV感染具有很好的抑制作用,对宿主细胞具有良好的生物相容性。结果表明,该复合物能直接失活病毒抑制病毒附着,从而防止RSV感染宿主细胞,对病毒感染具有预防和治疗作用。

综上所述,该研究结果表明,该复合物可能为RSV感染的抗病毒治疗提供新的思路。

原始出处:


Yang XX, Li CM, Li YF, Wang J, Huang CZ. Synergistic antiviral effect of curcumin functionalized graphene oxide against respiratory syncytial virus infection. Nanoscale. 2017 Oct 26;9(41):16086-16092. doi: 10.1039/c7nr06520e.

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    2017-12-03 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

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    2017-12-03 feather81
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    2017-12-02 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

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    2017-12-01 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2017-12-01 衣带渐宽

    学习

    0

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