JCEM:孕早期高甘油三酯水平与早产风险

2018-10-13 xing.T MedSci原创

由此可见,妊娠早期的高mTG水平不仅增加了OWO女性的早产风险,而且增加了BMI正常女性的早产风险。

产妇肥胖会增加早产的风险。已经明确肥胖与脂质代谢改变有关。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在调查早孕期间孕产妇高甘油三酯(mTG)水平与早产风险之间的关系,并按早孕体重指数(BMI)进行分层。

该研究为回顾性队列研究,参与者为49612名单胎妊娠妇女,她们在妊娠早期接受了空腹血清脂质筛查。该研究的主要观察指标为早产风险(总共<37周,早期28-33周;晚期34-36周)。

在入选的女性中,有2494人为早产,包括438例早期早产,2056例晚期早产。高mTG(>90th,2.04mM)与缩短的孕周相关。母亲TG水平增加,早期和晚期早产的风险增加,早期早产的高mTG相关风险最高(调整后比值比(AOR)为1.72,95%CI为1.30-2.29)。在按BMI分层后,高mTG与超重/肥胖(OWO,AOR为1.32,1.02-1.70)和正常BMI女性(1.36,1.16-1.59)的早产风险相关。在进一步的敏感性分析中,研究人员发现高mTG与OWO和正常BMI女性早产的风险较高有关(分别有AOR为1.54,1.07-2.22和1.62,1.34-1.96),尤其是早期早产(分别有AOR为2.47,1.19-5.10和2.50,1.65-3.78)。

由此可见,妊娠早期的高mTG水平不仅增加了OWO女性的早产风险,而且增加了BMI正常女性的早产风险。

原始出处:

Xian-hua Lin,et al.Maternal High Triglyceride Levels During Early Pregnancy and Risk of Preterm Delivery: A Retrospective Cohort Study.J Clin Endocrinol Metab. 2018. https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/jc.2018-01372/5126920?redirectedFrom=fulltext

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    2019-05-18 smallant2015
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    2019-06-23 achengzhao
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    2018-10-14 明月清辉

    谢谢分享,学习了

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