JACC:ACEI/ARB可降低左室辅助装置患者的胃肠道出血风险

2022-06-22 不详 MedSci原创

血管紧张素II受体的激活会促进血管生成,也可能通过转化生长因子(TGF)-β和血管生成素-2途径的激活导致动静脉畸形(AVM)。

血管紧张素II受体的激活会促进血管生成,也可能通过转化生长因子(TGF)-β和血管生成素-2途径的激活导致动静脉畸形(AVM)。本研究的目的旨在评估血管紧张素转换酶(ACE)抑制剂或血管紧张素受体阻滞剂(ARB)是否能降低左心室辅助装置(CF-LVAD)患者的主要肠出血(GIB)和AVM相关的GIB风险。

本研究纳入了111名CF-LVAD患者,经过平均2.1±1.4年时间的随访,那些在术后30天内接受有ACE抑制剂/ARB治疗的患者的GIB风险降低了57%([aHR]: 0.43; 95% [CI]: 0.19-0.97; p = 0.042),AVM相关的GIB风险降低了63%(aHR: 0.37; 95% CI: 0.16-0.84; p = 0.017)。另外,当每日平均赖诺普利等效ACE抑制剂/ARB剂量大于5 mg时,主要肠道出血的风险以剂量阈值的方式降低(aHR: 0.28; 95% CI: 0.09-0.85; p = 0.025)。

研究结果显示,对于左心室辅助装置患者,ACE抑制剂/ARB治疗可以降低主要胃肠道出血风险,可能与降低动静脉畸形风险有关。

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    2019-10-21 shanyongle
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    2019-12-27 hbwxf
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