中医脉络学说构建及其指导微血管病变防治取得重大突破

2019-12-27 高长安 科学网

当前心、脑、(糖)肾等临床重大疾病严重危害着人类的健康和生命。据统计,我国大约有2.9亿心血管病患者,每10秒钟就有1人死于心血管病;每 5 位死亡者中至少1人死于脑血管病;糖尿病患者达1.14亿,而出现糖尿病肾病的几率高达30-50%。

当前心、脑、(糖)肾等临床重大疾病严重危害着人类的健康和生命。据统计,我国大约有2.9亿心血管病患者,每10秒钟就有1人死于心血管病;每 5 位死亡者中至少1人死于脑血管病;糖尿病患者达1.14亿,而出现糖尿病肾病的几率高达30-50%。

微血管病变被认为是上述重大疾病临床疗效难以提高的关键因素。然而,因其机制不清、疗效不定、证据不足等原因,多年来国内外学者始终未有突破性进展。

《中国科学报》近日在络病研究与创新中药国家重点实验室采访获悉,中国工程院院士吴以岭领衔研发团队完成的“中医脉络学说构建及其指导微血管病变防治”项目取得重大突破 。

该团队依托两项国家973计划,历时10余年,首次系统构建脉络学说,建立“脉络-血管系统病”辨证诊断标准,提出脉络学说核心内容“营卫理论”,提出“调营卫气血”治疗用药规律。国家973计划专家组评价:“脉络学说营卫理论形成了指导微血管病变重大疾病防治的新理论,属于中医药学术研究的原创成果”。

12月24日,该研发团队成员之一、河北以岭医药研究院副院长魏聪博士接受《中国科学报》采访时表示,此项研究共有三个创新点。

创新点一:首次系统构建脉络学说,提出核心内容—营卫理论,建立“脉络-血管系统病”辨证标准,提出“调营卫气血”治疗用药规律,属重大理论。

创新点二:脉络学说指导微血管病变系列机制研究——揭示营气与血管内皮细胞、卫气与血管外膜及神经体液调节功能相关性,揭示“孙络-微血管”多维时空动态演变的复杂网络病变规律,揭示通络改善微血管血流灌注、保护组织细胞、改善脏器功能是治疗心、脑、(糖)肾重大疾病共性机制,治疗微血管病变核心机制是保护微血管内皮细胞。

创新点三:循证研究解决国际医学界重大难题——解决急性心梗无再流临床难题,为心功能不全伴室早提供新药物,填补窦缓伴室早快慢兼治、整合调律的药物治疗空白,明显提高慢性心衰临床疗效。芪苈强心胶囊治疗慢性心衰循证研究发表在国际循环顶尖杂志《美国心脏病学会杂志》,并被评为年度学术亮点:“让衰竭的心脏更加强劲——中国传统医学给我们的启示”。

目前,中医络病学已经被确定为国家中医药管理局重点学科和优势学科,被列为卫生部国家临床重点专科、国家中医药管理局区域诊疗中心、与北京阜外医院合作建立国家中管局重大疑难疾病中西医协作试点。通络中药通心络、参松养心、芪苈强心胶囊列入“十三五”规划教材《中医内科学》、人民卫生出版社《中西结合神经病学》《中西医结合内科学》和第9版西医《内科学》教材中,《络病学》同时在全国26家高校开课。

据悉,国家973计划专家组给与了其高度评价:本研究“创立了‘理论+临床+新药+实验+循证’一体化的中医学术创新与转化新模式,中医传统理论创新与现代科学技术相结合,产生重大原创成果,为中医药传承与创新发展做出了示范。”

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    2019-12-29 mgqwxj
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    2019-12-28 运动yd

    中医中药,大多被人诋毁,不过梅斯里总是客观公正的

    0