Neurology:难治性慢性丛集性头痛深层脑刺激更佳位点研究

2017-10-15 zhangfan MedSci原创

研究人员考察了难治性慢性丛集性头痛深层脑刺激的最佳位点,加深了对疾病生理病理以及治疗机制的认识

近日研究人员探讨了深部脑电刺激治疗难治性慢性丛集性头痛的作用机制及腹侧被盖区的最佳靶点。

7例难治性慢性丛集性头痛患者首先进行术前高空间角分辨扩散MRI检查,根据MRI引导和成像对5名患者植入单侧电极,2名植入双侧电极。术后12个月评估患者的头痛负荷,利用概率成像确定减轻疼痛30%以上患者的大脑应答激活体积和大脑连接情况。

研究中未发生手术相关并发症,平均随访34 ± 14 个月。研究发现电刺激可减少76 ± 33%头痛负荷、减少46 ± 41%的严重头痛程度、减少58 ± 41%的头痛频率以及 51 ± 46%的头痛持续时间。6名患者对治疗有响应。头痛减少的最大负荷与第三脑室外侧6毫米,后2毫米,表面1毫米的区域激活有关。大部分患者的治疗响应位点位于连接三叉神经系统和其他脑干核团,调控下丘脑、前额叶和颞叶内侧区的痛觉的三叉神经-下丘脑通道。

研究人员考察了难治性慢性丛集性头痛深层脑刺激的最佳位点,加深了对疾病生理病理以及治疗机制的认识。

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    2018-01-22 yinhl1978
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    2017-10-17 freve
  5. [GetPortalCommentsPageByObjectIdResponse(id=2000136, encodeId=23632000136c0, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Jan 22 14:36:00 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457658, encodeId=1e3d145e6583a, content=<a href='/topic/show?id=f9f684e27d6' target=_blank style='color:#2F92EE;'>#脑刺激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84727, encryptionId=f9f684e27d6, topicName=脑刺激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Oct 17 00:36:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458498, encodeId=4e691458498a3, content=<a href='/topic/show?id=175e20982ac' target=_blank style='color:#2F92EE;'>#丛集性头痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20982, encryptionId=175e20982ac, topicName=丛集性头痛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd1b6086520, createdName=hjwang81, createdTime=Tue Oct 17 00:36:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528395, encodeId=fd0f1528395f7, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Tue Oct 17 00:36:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253289, encodeId=addd253289d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Mon Oct 16 06:33:13 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253118, encodeId=2084253118ce, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sun Oct 15 11:55:30 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253088, encodeId=7010253088b1, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Oct 15 09:44:41 CST 2017, time=2017-10-15, status=1, ipAttribution=)]
    2017-10-16 yfjms

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2000136, encodeId=23632000136c0, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Jan 22 14:36:00 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457658, encodeId=1e3d145e6583a, content=<a href='/topic/show?id=f9f684e27d6' target=_blank style='color:#2F92EE;'>#脑刺激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84727, encryptionId=f9f684e27d6, topicName=脑刺激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Oct 17 00:36:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458498, encodeId=4e691458498a3, content=<a href='/topic/show?id=175e20982ac' target=_blank style='color:#2F92EE;'>#丛集性头痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20982, encryptionId=175e20982ac, topicName=丛集性头痛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd1b6086520, createdName=hjwang81, createdTime=Tue Oct 17 00:36:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528395, encodeId=fd0f1528395f7, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Tue Oct 17 00:36:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253289, encodeId=addd253289d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Mon Oct 16 06:33:13 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253118, encodeId=2084253118ce, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sun Oct 15 11:55:30 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253088, encodeId=7010253088b1, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Oct 15 09:44:41 CST 2017, time=2017-10-15, status=1, ipAttribution=)]
    2017-10-15 戒馋,懒,贪

    谢谢分享.学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2000136, encodeId=23632000136c0, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Jan 22 14:36:00 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457658, encodeId=1e3d145e6583a, content=<a href='/topic/show?id=f9f684e27d6' target=_blank style='color:#2F92EE;'>#脑刺激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84727, encryptionId=f9f684e27d6, topicName=脑刺激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Oct 17 00:36:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458498, encodeId=4e691458498a3, content=<a href='/topic/show?id=175e20982ac' target=_blank style='color:#2F92EE;'>#丛集性头痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20982, encryptionId=175e20982ac, topicName=丛集性头痛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd1b6086520, createdName=hjwang81, createdTime=Tue Oct 17 00:36:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528395, encodeId=fd0f1528395f7, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Tue Oct 17 00:36:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253289, encodeId=addd253289d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Mon Oct 16 06:33:13 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253118, encodeId=2084253118ce, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sun Oct 15 11:55:30 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253088, encodeId=7010253088b1, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Oct 15 09:44:41 CST 2017, time=2017-10-15, status=1, ipAttribution=)]
    2017-10-15 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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