Cell Death & Disease:MiRNA-671-5p通过靶向NFIA/CRYAB途径促进前列腺癌的发展和转移

2020-11-19 AlexYang MedSci原创

前列腺癌(PCa)是男性恶性肿瘤致死的第二位死因,转移是PCa患者死亡的主要原因。微RNAs(miRNAs)在肿瘤的发展和转移中起着重要的调控作用。

前列腺癌(PCa)是男性恶性肿瘤致死的第二位死因,转移是PCa患者死亡的主要原因。微RNAs(miRNAs)在肿瘤的发展和转移中起着重要的调控作用。

最近,有研究人员通过生物信息学分析发现了13个与PCa转移相关的miRNAs。此外,他们还发现miR-671-5p在转移性PCa组织中增加,其高表达预示着PCa的不良预后。MiR-671-5p可以促进PCa细胞在体外和体内的增殖、迁移和侵袭。研究人员还证实了miR-671-5p能够直接与NFIA mRNA的3'非翻译区结合,NFIA直接与CRYAB的启动子结合。NFIA和CRYAB的高表达与PCa患者的晚期临床病理特征和转移状态呈负相关。

NFIA和CRYAB表达与PCa临床病理特征的关联情况

最后,研究人员指出,他们的研究表明了miR-671-5p能够通过抑制NFIA/CRYAB途径促进PCa的发展和转移。

原始出处:

Zhiguo Zhu, Lianmin Luo, Qian Xiang et al. MiRNA-671-5p Promotes prostate cancer development and metastasis by targeting NFIA/CRYAB axis. Cell Death & Disease. Nov 2020

 

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    2021-01-16 smallant2002
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    2021-03-13 维他命
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    2021-06-21 zhaojie88
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    2020-11-21 Homburg
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    2020-11-21 cy0328
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    2020-11-19 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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过敏性鼻炎(AR)是一种常见的慢性疾病,主要特征为鼻黏膜上的炎症。MicroRNA(miRNAs)在AR中的作用已经有所阐释,尤其是调控炎症响应中具有作用。最近,有研究人员在AR小鼠中探索了miR-3

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缺少配体结合域的雄激素受体剪接变异体7(ARv7)越来越被认为是导致前列腺癌(PCa)患者对恩杂鲁胺(Enz)耐药的关键因子。然而,ARv7的表达是如何被调控的详细机制以及它是否需要其他因子来诱导最大

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治疗诱导的神经内分泌前列腺癌(NEPC)是去势抵抗性前列腺癌(CRPC)的一种极具侵袭性的亚型;随着恩杂鲁胺(ENZ)和阿比特龙等高效雄激素受体(AR)通路抑制剂(API)的广泛使用,其发病率越来越高

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活性生殖细胞恶性肿瘤表达高水平的特异性循环微RNA(miRNAs),其中包括了miR-371a-3p(miR371),而在畸胎瘤中检测不到。由于畸胎瘤存在恶性转化和畸胎瘤综合征不断增加的风险,因此迫切