Heart:55岁及以上人群胸主动脉直径的纵向变化

2022-05-11 MedSci原创 MedSci原创

老年男性和女性的胸主动脉直径均有一定程度的增大。与胸主动脉直径变化相关的因素包括性别、年龄、BMI和舒张压。

胸主动脉瘤(TAA)通常被定义为胸主动脉直径≥40mm,与主动脉夹层甚至猝死的风险增加相关。目前,关于年龄相关性胸主动脉直径变化的纵向数据很少。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,为了更好地理解正常变化并确定影响这一过程的因素,研究人员旨在报道老年人群中男女特异性和年龄特异性主动脉的生长速率,并明确与生长速率相关的因素。

从基于人群的前瞻性鹿特丹研究中,943名参与者(52.0%为女性,中位年龄为基线为65岁(62-68))接受了一系列非增强心脏CT检查。研究人员在在两个时间点测量了升主动脉(AA)和降主动脉(DA)的直径,并表达了绝对和相对差异。研究人员进行了线性混合效应分析以确定与主动脉直径变化相关的决定因素。

男性平均AA直径为37.3±3.6 mm,女性为34.7±3.2 mm,男性平均DA直径为29.6±2.3 mm,女性平均DA直径为26.9±2.2 mm。随访期间(平均扫描间隔时间为14.1±0.3年),AA和DA的直径绝对变化中值均为1 mm(0-2)。男性AA直径每10年的绝对变化量显著大于女性(0.72 mm/10年(0.00-1.43) vs 0.70 mm/10年(0.00-1.41),p=0.006), AD直径的绝对变化量(0.71 mm/10年(0.00-1.42) vs 0.69 mm/10年(0.00-1.36),p=0.008)。随访期间,男性和女性主动脉直径的相对变化无显著差异。年龄、男性、较高的身体质量指数(BMI)和较高的舒张压(DBP)与随着时间的推移AA和DA直径的增加相关,并且具有显著的统计学意义。

由此可见,老年男性和女性的胸主动脉直径均有一定程度的增大。与胸主动脉直径变化相关的因素包括性别、年龄、BMI和舒张压。

原始出处:

Carlijn G E Thijssen.et al.Longitudinal changes of thoracic aortic diameters in the general population aged 55 years or older.heart.2022.https://heart.bmj.com/content/early/2022/04/28/heartjnl-2021-320574

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2003994, encodeId=1e29200399421, content=<a href='/topic/show?id=cdac840e95e' target=_blank style='color:#2F92EE;'>#胸主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84079, encryptionId=cdac840e95e, topicName=胸主动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b70c362, createdName=jiadan198782, createdTime=Sat Feb 25 08:57:27 CST 2023, time=2023-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218903, encodeId=d7241218903c2, content=好东西,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0be2111725, createdName=萌宝嘟嘟, createdTime=Wed May 11 22:59:30 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357915, encodeId=cc32135e915c3, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed May 11 09:57:27 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415834, encodeId=d45a141583428, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Wed May 11 09:57:27 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563609, encodeId=4d4a156360973, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed May 11 09:57:27 CST 2022, time=2022-05-11, status=1, ipAttribution=)]
    2022-05-11 萌宝嘟嘟

    好东西,谢谢分享

    0

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    2022-05-11 zhaojie88
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    2022-05-11 slcumt

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