PLOS ONE:吸烟会增加膀胱癌侵袭性吗?

2018-03-25 海北 MedSci原创

最近,来自Radboud大学医疗中心的研究人员探讨了初诊时吸烟强度与膀胱癌侵袭性的关系。

最近,来自Radboud大学医疗中心的研究人员探讨了初诊时吸烟强度与膀胱癌侵袭性的关系。其在荷兰癌症登记处回顾性地分析了1995-2011年间75岁以下被诊断患有膀胱癌(BC)的患者,并邀请他们就BC的遗传性和生活方式危险因素进行研究。
通过邮寄调查问卷,研究人员收集了患者自我报告吸烟史的信息,并根据肿瘤分期和分级确定其进展风险。然后,研究人员使用多项logistic回归分析吸烟强度与肿瘤侵袭性的关系。
该UBC研究人群包括了323名(17.4%)从不吸烟者,870名(46.8%)前吸烟者,和630名(33.9%)当前吸烟者。
在既往吸烟者中,与低危非肌层浸润性膀胱癌(NMIBC)相比, 吸烟量高是高危NMIBC的危险因素(OR:每支烟1.02,95%CI:1.00-1.03; OR:1.03, 95%CI:1.01-1.05)。 随着前吸烟者吸烟持续时间的增加,研究人员观察到更具侵袭性的癌症类型(高风险NMIBC和MIBC)的风险随剂量显著增加(p趋势分别为0.035和0.008)。在当前吸烟者中未观察到吸烟强度变量的显着关联。戒烟时间越长,侵袭性癌症发生率越低。
因此,研究人员观察到,前吸烟者随着吸烟强度增加,更具侵袭性的肿瘤类型的风险微弱增加,但这种关联在当前吸烟者中不存在。这一相互矛盾的结果可能表明吸烟强度与膀胱癌侵袭性之间没有强相关性。

原始出处:
André L. A. Barbosa et al. Smoking intensity and bladder cancer aggressiveness at diagnosis. PLOS ONE, 2018; DOI: https://doi.org/10.1371/journal.pone.0194039

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    2018-03-28 lou.minghong

    吸烟有百害而无一利!

    0

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    2018-03-26 sunyl07
  4. 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likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:23:59 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-03-25 1dea4a7em68(暂无匿称)

    吸烟可以直接和间接地导致多种疾病的发生

    0

  5. 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likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:23:59 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-03-25 龙胆草

    学习谢谢分享

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:24:33 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299463, encodeId=95cf29946322, content=也是考验一个人的定力, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:24:08 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299462, encodeId=54d429946290, content=这个是社会公德的表现之一, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:23:59 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-03-25 Jackie Li

    学习

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sun Mar 25 09:17:59 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299467, encodeId=8f9f29946e9d, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Mar 25 07:33:50 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299464, encodeId=b9bb299464e3, content=个人觉得吸烟还是和很多癌变相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:24:33 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299463, encodeId=95cf29946322, content=也是考验一个人的定力, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:24:08 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299462, encodeId=54d429946290, content=这个是社会公德的表现之一, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:23:59 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-03-25 1dd8c52fm63(暂无匿称)

    了解了解.继续关注

    0

  8. 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likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:23:59 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-03-25 雾夜芭蕾

    个人觉得吸烟还是和很多癌变相关

    0

  9. 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likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:23:59 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-03-25 雾夜芭蕾

    也是考验一个人的定力

    0

  10. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:24:33 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299463, encodeId=95cf29946322, content=也是考验一个人的定力, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:24:08 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299462, encodeId=54d429946290, content=这个是社会公德的表现之一, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sun Mar 25 07:23:59 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-03-25 雾夜芭蕾

    这个是社会公德的表现之一

    0

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