Am J Gastroenterol:胃底腺息肉伴不典型增生的临床病理学评价

2017-05-03 zhangfan MedSci原创

本实验涉及的25名有FGPDs却无FAP患者,通过内镜,临床和遗传等方式检测均无FAP症状,发生FGPDs不预示FAP

胃底腺息肉(FGPS)很少发生在发育异常表面上皮。回顾性分析表明,胃底腺息肉伴表面上皮发育异常(FGPDs)是家族性腺瘤性息肉病(FAP)强有力的标志物。因其显著关联性,确证的散发性FGPD都要进行FAP临床评估。近日研究人员对于FGPDs与FAP相关性进行了研究。

研究对2004年至2015年间活检验证的非FAP的FGPDs患者进行统计并检测其病情进展。

研究中共发现25名患有FGPDs的非FAP患者(占FGPDs患者的11.6%, FGPs患者的 1.0%),4例患者有胃息肉或胃肠道癌家族史。临床监控手段包括切除和胃内镜监测(44%),内镜检查(32%),无随访(24%),结肠镜转诊(12%),遗传咨询(4%)。结肠镜检查记录报告了7起累计腺瘤,平均随访4.4年,没有FAP临床证据,胃癌,死亡或手术发生,11名接受APC和MUTYH基因组测试的患者也无突变发生。

研究认为对于本实验涉及的25名有FGPDs却无FAP患者,通过内镜,临床和遗传等方式检测均无FAP症状,发生FGPDs不预示FAP。

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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193514, encodeId=5b9919351487, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 04 06:34:35 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-11-21 yaanren
  5. 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href='/topic/show?id=4fd1e102257' target=_blank style='color:#2F92EE;'>#病理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71022, encryptionId=4fd1e102257, topicName=病理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8ce7226273, createdName=jktdtl, createdTime=Thu May 04 15:00:00 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193579, encodeId=e5b71935e9dd, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Thu May 04 07:43:34 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193514, encodeId=5b9919351487, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 04 06:34:35 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 huagfeg
  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193514, encodeId=5b9919351487, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 04 06:34:35 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 jktdtl
  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193514, encodeId=5b9919351487, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 04 06:34:35 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 医艺依意

    学习了,谢谢分享

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193514, encodeId=5b9919351487, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 04 06:34:35 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 半夏微凉

    学习了谢谢分享

    0