Clinica Chimica Acta:正常范围内丙氨酸氨基转移酶与冠心病患者预后呈负相关

2019-10-18 gladiator MedSci原创

目前,有关丙氨酸氨基转移酶(ALT)与冠心病(CAD)患者预后关系的数据有限。本研究的目的是评估ALT与冠心病患者预后的关系。

目前,有关丙氨酸氨基转移酶(ALT)与冠心病(CAD)患者预后关系的数据有限。本研究的目的是评估ALT与冠心病患者预后的关系。

该研究包括9523例经血管造影证实的冠心病患者,他们接受了经皮冠状动脉介入治疗。所有患者的ALT基线测量值均可用于分析。主要结果是3年的心脏死亡率。

将患者分为三组:第一三分位数内的ALT组(ALT 2.0 U / L≤17.0U / L n = 3276例),第二三分位数内的ALT组(ALT> 17.0 U / L ≤26.0U / L n = 3075例)和ALT在第三个三分位数之内的组(> 26 / U / L≤50.0U / L n = 3172例)。 心脏死亡(主要结局)发生在441例患者中:其中2017.1%),1264.7%)和1144.0%)分别发生在第一,第二和第三ALT三分位数患者中(百分比代表Kaplan– Meier估计3年心脏死亡率); 调整后的危险比= 1.4395%置信区间1.111.85P = 0.006,按ALT对数标度每降低1个单位计算一次。 带有无ALT基线变量的心脏死亡率的多变量模型的C统计量为0.827 [0.801–0.853]P <0.001,并入ALT后增加到0.832 [0.806-0.857]P <0.001P = 0.020

在冠心病患者中,ALT3年心脏死亡风险呈负相关,且独立存在。低ALT可能反映传统心血管危险因素介导的心血管风险较差。

原始出处:

Gjin Ndrepepa,Stefan Holdenrieder,Inverse association of alanine aminotransferase within normal range with prognosis in patients with coronary artery disease

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    2020-01-16 windight
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    2019-10-20 hmwwww
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    2019-10-19 qingfengqishi5

    学习了,学习了

    0

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