Clin Gastroenterology H:增加体力活动与非酒精性脂肪肝患者的较低死亡率相关

2021-06-13 MedSci原创 MedSci原创

非酒精性脂肪肝(NAFLD)是世界上最流行的慢性肝病,影响了美国约三分之一的人口,已成为美国肝衰竭的主要原因。

      非酒精性脂肪肝(NAFLD)是世界上最流行的慢性肝病,影响了美国约三分之一的人口,已成为美国肝衰竭的主要原因。尽管目前还没有批准的用于治疗NAFLD的药物上市,但改变生活方式仍然是有效的治疗手段之一,尽管许多人发现他们很难真正的实现既定的锻炼目标。体育锻炼(PA)是生活方式改变的关键组成部分,但是如何定量测量患者的PA强度是亟待解决的问题,本项研究采用加速度计测量的 PA 来衡量是否与 NAFLD 患者的全因和特定原因死亡率相关。

 

       研究人员收集了2003 年至 2006 年美国成人(年龄≥20 岁)国家健康和营养检查调查数据并进行了纵向分析,并收集了截至 2015 年 12 月的死亡率数据。NAFLD 是根据肝脂肪变性指数或美国脂肪肝指数评分定义的。PA 的测量对象是在 7 天期间内佩戴加速度计 至少10 小时/天的参与者,并将其归类为总 PA、中度至剧烈 PA (MVPA) 和久坐行为三类患者。

 

       在平均 10.6 年的随访期间,在年龄和性别调整模型中,增加总 PA 的持续时间与任何原因导致的死亡风险降低均相关([HR],0.52;95% CI,0.32–0.86;P = .001)。增加 MVPA 的持续时间与 NAFLD 个体因任何原因死亡的风险降低有关。此外,在 NAFLD 患者中,较长的总 PA 与较低的血管疾病相关死亡风险相关(HR,0.28;95% CI,0.08-0.98;P= .007)。同时研究人员还发现增加久坐行为的持续时间不会影响 NAFLD 患者的全因或特定原因死亡率。

图:体育锻炼与NAFLD的相关性

       本项研究证实通过7天内的总PA和 MVPA 强度与NAFLD 患者的全因死亡率和心血管死亡率较低相关。

 

 

原始出处:

Donghee Kim. Et al. Physical Activity, Measured Objectively, Is Associated With Lower Mortality in Patients With Nonalcoholic Fatty Liver Disease. Clinical Gastroenterology and Hepatology.2021.

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    2022-02-28 许安
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    2021-06-14 亭儿789

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