J Oral Biol Craniofac Res:阿仑膦酸钠可有效治疗牙周炎,尤其是非吸烟者

2019-06-20 不详 网络

牙周炎是微生物起源的进行性疾病,涉及由宿主炎症和免疫反应引起的牙齿支持组织的丧失。多年来预防和治疗牙周疾病的标准方法是机械治疗,如果需要外科手术,研究人员考虑创建一种治疗方式,通过改变宿主反应,可能会干扰破坏性宿主机制,影响最终结果疾病过程。本研究旨在探讨局部递送1%阿仑膦酸钠(ALN)凝胶作为刮治和根面平整(SRP)辅助治疗吸烟者和非吸烟者慢性牙周炎牙周袋的功效。选择年龄在30-50岁之间的慢性

牙周炎是微生物起源的进行性疾病,涉及由宿主炎症和免疫反应引起的牙齿支持组织的丧失。多年来预防和治疗牙周疾病的标准方法是机械治疗,如果需要外科手术,研究人员考虑创建一种治疗方式,通过改变宿主反应,可能会干扰破坏性宿主机制,影响最终结果疾病过程。

本研究旨在探讨局部递送1%阿仑膦酸钠(ALN)凝胶作为刮治和根面平整(SRP)辅助治疗吸烟者和非吸烟者慢性牙周炎牙周袋的功效。

选择年龄在30-50岁之间的慢性牙周炎患者的60个骨下袋。该研究包括2组吸烟者和非吸烟者。配制阿仑膦酸盐的基于凝胶的药物递送系统。根面平整后,分别将0.1ml阿仑膦酸盐凝胶和0.1ml安慰剂凝胶置于实验和对照部位。在基线,3个月和6个月记录临床和放射学参数。

结果显示,与安慰剂相比,阿仑膦酸盐可有效改善临床和放射学参数。与吸烟组相比,阿仑膦酸钠在非吸烟组中表现出更好的结果。

该研究显示对照和实验部位的临床参数均有所改善。然而,与对照部位(安慰剂)相比,实验部位(阿仑膦酸盐)显示出更大的改善。非吸烟者阿仑膦酸钠组在放射学上测量了牙槽嵴高度和缺损填充的明显增加。

原始出处:

Sheokand V, Chadha VS, et al., The comparative evaluation of 1% alendronate gel as local drug delivery system in chronic periodontitis in smokers and non smokers: Randomized clinical trial. J Oral Biol Craniofac Res. 2019 Apr-Jun;9(2):198-203. doi: 10.1016/j.jobcr.2018.05.006. Epub 2018 Jun 6.

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    2019-12-24 小几洁
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    2019-11-09 sunylz
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    2020-02-26 仁者大医
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