Cornea:抗组胺药物释放隐形眼镜可用于治疗眼部过敏性瘙痒

2020-08-17 MedSci原创 MedSci原创

本研究中,两项多中心、随机、安慰剂对照测试了一种对基于隐形眼镜(CL)的抗组胺酮替芬药物输送系统。

本研究中,两项多中心、随机、安慰剂对照测试了一种对基于隐形眼镜(CL)的抗组胺酮替芬药物输送系统。

试验镜片为含0.019mg酮替芬的依他非康A;对照镜片为无添加药物的依他非康A。受试者随机分为3个治疗组。第1组单眼接受测试镜片,对侧眼接受对照镜片;按1:1的比例随机选择接受测试镜片的眼睛。第2组双眼接受测试镜片,第3组双眼接受对照镜片。过敏原挑战在2次单独的随访中进行:戴上眼镜后,受试者在15分钟(对测试开始)和12小时(对测试持续时间)进行测试。主要终点是使用半单位步长的0到4的尺度测量的眼部瘙痒。次要终点包括睫状体、结膜和外膜高血症。

 

结果显示,与佩戴对照镜片的眼睛相比,佩戴测试镜片的眼睛的平均瘙痒评分较低,表明测试镜片有效地降低了过敏反应。两项试验在发病和持续时间上,瘙痒的平均差异均有统计学和临床意义(平均分差≥1)。

综上所述,这项大规模的评估(n = 244)是首次证明CL递送治疗眼部过敏的疗效。结果与直接局部给药相当,并表明透镜/酮替芬组合可以为CL佩戴者提供同时矫正视力和治疗眼部过敏的手段。

 

原始出处:

 

Brian PallPaul Gomes, et al., Management of Ocular Allergy Itch With an Antihistamine-Releasing Contact Lens. Cornea. 2019 Jun;38(6):713-717. doi: 10.1097/ICO.0000000000001911.

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GetPortalCommentsPageByObjectIdResponse(id=1311576, encodeId=2dd613115e611, content=<a href='/topic/show?id=b53e5560953' target=_blank style='color:#2F92EE;'>#抗组胺药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55609, encryptionId=b53e5560953, topicName=抗组胺药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Wed Aug 19 12:41:22 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546069, encodeId=78bd15460696f, content=<a href='/topic/show?id=a6b655610ca' target=_blank style='color:#2F92EE;'>#抗组胺药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55610, encryptionId=a6b655610ca, topicName=抗组胺药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8cec13863916, createdName=siiner, createdTime=Wed Aug 19 12:41:22 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560421, encodeId=c5c11560421b7, content=<a href='/topic/show?id=4ff1e294238' target=_blank style='color:#2F92EE;'>#眼镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72942, encryptionId=4ff1e294238, topicName=眼镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=508115130308, createdName=zhangfenasdf, createdTime=Wed Aug 19 12:41:22 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566430, encodeId=98ed15664304a, content=<a href='/topic/show?id=4ff1e294238' target=_blank style='color:#2F92EE;'>#眼镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72942, encryptionId=4ff1e294238, topicName=眼镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=508115130308, createdName=zhangfenasdf, createdTime=Wed Aug 19 12:41:22 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2020-08-19 ms5000000741733160

    👍

    0

  5. 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GetPortalCommentsPageByObjectIdResponse(id=1311576, encodeId=2dd613115e611, content=<a href='/topic/show?id=b53e5560953' target=_blank style='color:#2F92EE;'>#抗组胺药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55609, encryptionId=b53e5560953, topicName=抗组胺药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Wed Aug 19 12:41:22 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546069, encodeId=78bd15460696f, content=<a href='/topic/show?id=a6b655610ca' target=_blank style='color:#2F92EE;'>#抗组胺药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55610, encryptionId=a6b655610ca, topicName=抗组胺药物)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=72942, encryptionId=4ff1e294238, topicName=眼镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=508115130308, createdName=zhangfenasdf, createdTime=Wed Aug 19 12:41:22 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2020-08-19 ms5000000741733160

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1776096, encodeId=e9551e7609629, content=<a href='/topic/show?id=508ae2913d6' target=_blank style='color:#2F92EE;'>#眼部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72913, encryptionId=508ae2913d6, topicName=眼部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=126338864246, createdName=huiwelcome, createdTime=Sat Jul 24 11:41:22 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742164, encodeId=c9761e4216461, content=<a href='/topic/show?id=a830e7734a0' target=_blank style='color:#2F92EE;'>#组胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77734, encryptionId=a830e7734a0, topicName=组胺)], attachment=null, authenticateStatus=null, createdAvatar=null, 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GetPortalCommentsPageByObjectIdResponse(id=1311576, encodeId=2dd613115e611, content=<a href='/topic/show?id=b53e5560953' target=_blank style='color:#2F92EE;'>#抗组胺药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55609, encryptionId=b53e5560953, topicName=抗组胺药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Wed Aug 19 12:41:22 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546069, encodeId=78bd15460696f, content=<a href='/topic/show?id=a6b655610ca' target=_blank style='color:#2F92EE;'>#抗组胺药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55610, encryptionId=a6b655610ca, topicName=抗组胺药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8cec13863916, createdName=siiner, createdTime=Wed Aug 19 12:41:22 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560421, encodeId=c5c11560421b7, content=<a href='/topic/show?id=4ff1e294238' target=_blank style='color:#2F92EE;'>#眼镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72942, encryptionId=4ff1e294238, topicName=眼镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=508115130308, createdName=zhangfenasdf, createdTime=Wed Aug 19 12:41:22 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566430, encodeId=98ed15664304a, content=<a href='/topic/show?id=4ff1e294238' target=_blank style='color:#2F92EE;'>#眼镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72942, encryptionId=4ff1e294238, topicName=眼镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=508115130308, createdName=zhangfenasdf, createdTime=Wed Aug 19 12:41:22 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2020-08-19 listen318
  7. [GetPortalCommentsPageByObjectIdResponse(id=1776096, encodeId=e9551e7609629, content=<a href='/topic/show?id=508ae2913d6' target=_blank style='color:#2F92EE;'>#眼部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72913, encryptionId=508ae2913d6, topicName=眼部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=126338864246, createdName=huiwelcome, createdTime=Sat Jul 24 11:41:22 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742164, encodeId=c9761e4216461, content=<a href='/topic/show?id=a830e7734a0' target=_blank style='color:#2F92EE;'>#组胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77734, encryptionId=a830e7734a0, topicName=组胺)], attachment=null, authenticateStatus=null, createdAvatar=null, 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GetPortalCommentsPageByObjectIdResponse(id=1311576, encodeId=2dd613115e611, content=<a href='/topic/show?id=b53e5560953' target=_blank style='color:#2F92EE;'>#抗组胺药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55609, encryptionId=b53e5560953, topicName=抗组胺药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Wed Aug 19 12:41:22 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546069, encodeId=78bd15460696f, content=<a href='/topic/show?id=a6b655610ca' target=_blank style='color:#2F92EE;'>#抗组胺药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55610, encryptionId=a6b655610ca, topicName=抗组胺药物)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  8. 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  9. 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