Tocilizumab和sarilumab降低了COVID-19重症患者的死亡风险

2021-01-08 Allan MedSci原创

近日,REMAP CAP研究发现,Tocilizumab和sarilumab可将COVID-19重症患者的死亡率降低8.5%,还可以缩短患者的康复时间。

近日,REMAP CAP研究发现,Tocilizumab和sarilumab可将COVID-19重症患者的死亡率降低8.5%,还可以缩短患者的康复时间。Tocilizumab和sarilumab还使重症患者在ICU花费的时间减少了约一周。英国卫生部长Matt Hancock说:“这项结果是摆脱COVID-19大流行的又一个里程碑式进展,当将其添加到已经推出的疫苗和治疗方法中时,它们将在战胜COVID-19过程中发挥重要作用”。

REMAP CAP研究涉及来自英国等六个国家的约800例重症患者。另一项研究(RECOVERY试验)先前发现,地塞米松使COVID-19重症患者的死亡率减少了三分之一。据英国广播公司的报道,与Tocilizumab和sarilumab相比,地塞米松的成本相对较低(每疗程约5英镑),而Tocilizumab和sarilumab的成本约为750-1000英镑。

但是,REMAP CAP研究的首席研究员Anthony Gordon教授评论说:“Tocilizumab和sarilumab在挽救患者生命方面具有巨大优势”。

 

原始出处:

http://www.pharmatimes.com/news/tocilizumab_and_sarilumab_cut_risk_of_death_in_severe_covid-19_patients_1360960

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1912510, encodeId=8a4d1912510ac, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri Oct 01 01:21:58 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256042, encodeId=337812560420f, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284115, encodeId=ed861284115d7, content=<a href='/topic/show?id=cdb79594643' target=_blank style='color:#2F92EE;'>#重症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95946, encryptionId=cdb79594643, topicName=重症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914974, encodeId=02289149e4a7, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 20:18:09 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
    2021-10-01 snf701207
  2. [GetPortalCommentsPageByObjectIdResponse(id=1912510, encodeId=8a4d1912510ac, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri Oct 01 01:21:58 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256042, encodeId=337812560420f, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284115, encodeId=ed861284115d7, content=<a href='/topic/show?id=cdb79594643' target=_blank style='color:#2F92EE;'>#重症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95946, encryptionId=cdb79594643, topicName=重症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914974, encodeId=02289149e4a7, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 20:18:09 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1912510, encodeId=8a4d1912510ac, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri Oct 01 01:21:58 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256042, encodeId=337812560420f, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284115, encodeId=ed861284115d7, content=<a href='/topic/show?id=cdb79594643' target=_blank style='color:#2F92EE;'>#重症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95946, encryptionId=cdb79594643, topicName=重症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914974, encodeId=02289149e4a7, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 20:18:09 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1912510, encodeId=8a4d1912510ac, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri Oct 01 01:21:58 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256042, encodeId=337812560420f, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284115, encodeId=ed861284115d7, content=<a href='/topic/show?id=cdb79594643' target=_blank style='color:#2F92EE;'>#重症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95946, encryptionId=cdb79594643, topicName=重症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914974, encodeId=02289149e4a7, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 20:18:09 CST 2021, time=2021-01-09, status=1, ipAttribution=)]

相关资讯

Arthritis Rheumatol:Tocilizumab可有效治疗JIA相关葡萄膜炎

近期有研究称,对于重症幼年特发性关节炎相关的葡萄膜炎、既往常规免疫抑制药物和至少一种抗肿瘤坏死因子剂治疗失败的患者,Tocilizumab治疗是有效的。 研究人员进行了一项多中心研究,纳入了25例重症幼年特发性关节炎相关的葡萄膜炎、既往常规免疫抑制药物和至少一种抗肿瘤坏死因子剂治疗失败的患者,治疗药物包括阿达木单抗(n = 24)、依那西普(n =8)、英夫利昔单抗(n =7)、阿巴西普(n

2019年ARVO:Tocilizumab显著减少巨细胞动脉炎的发作次数

根据2019年视觉和眼科学研究协会年会(ARVO)的一项回顾性分析结果,Tocilizumab的治疗与巨细胞动脉炎(GCA)患者的发作次数的显著减少有关。

NEJM:Tocilizumab用于新冠肺炎住院患者的治疗

Tocilizumab治疗不能降低新冠肺炎患者插管或死亡风险

Lancet Rheumatol:重症监护室的COVID-19患者采用Tocilizumab治疗对预后的影响

Tocilizumab,是一种靶向白介素-6受体的单克隆抗体,有人认为它或可减轻重度COVID-19相关的细胞因子风暴综合征。本研究旨评估该药物对重症COVID-19患者预后的影响。

Lancet respirat med:托珠单抗治疗系统性硬化症的3期临床试验结果

托珠单抗(tocilizumab)是一种抗白介素6受体抗体,已有的2期试验提示其在系统性硬化症中具有一定疗效。本研究进一步开展了一项随机对照3期试验,以评估托珠单抗系统性硬化症的疗效和安全性。

喜讯!FDA授予罗氏抗炎药Actemra/RoActemra第2个突破性药物资格,治疗巨细胞动脉炎(GCA)

瑞士制药巨头罗氏(Roche)抗炎药Actemra/RoActemra(tocilizumab,托珠单抗)近日在美国监管方面传来喜讯。FDA已授予Actemra/RoActemra治疗巨细胞动脉炎(GCA)的突破性药物资格(BTD),这也是该药在美国监管方面获得的第2个突破性药物资格,之前,FDA于2015年6月授予该药治疗系统性硬化症(SSc)的BTD。值得一提的是,此次BTD,也是罗氏自2

拓展阅读

Biomedicines:2型糖尿病住院患者COVID-19的长期预后

在T2D合并COVID-19患者中,随访观察到住院死亡率、卒中和心血管住院率增加。

Cureus:2型糖尿病状态、糖尿病并发症严重程度指数评分及其与COVID-19严重程度的关系

与非糖尿病患者相比,我们样本中的糖尿病患者发生COVID-19不良临床结果和住院死亡率的几率更高。

Lancet Infect Dis:口服VV116用于治疗轻中度COVID-19成人患者的有效性和安全性评价

目前,治疗COVID-19的医疗需求仍未得到满足,新型抗病毒药物-VV116可用于治疗轻中度COVID-19成人患者,能够显著缩短临床症状持续时间,与其他药物较少发生药物间相互作用,且安全性良好。

论文解读|Yihua Wang教授团队新研究揭示了揭示COVID-19对肺癌治疗和研究的深远影响

该文章揭示了此次大流行对肺癌治疗、临床试验、研究活动的影响。

JAMA Intern Med:COVID-19相关急性肾损伤与长期肾脏结果

与患有其他疾病相关AKI的患者相比,COVID-AKI住院幸存者的MAKE发生率、长期肾功能下降和死亡率均显著较低。

【解读分享】2024 PIDS共识声明:儿童和青少年COVID-19预防和管理指南

本文主要针对儿童和青少年COVID-19预防和管理提供指导建议,涉及COVID-19的危险分层、治疗和预防,点击即可下载查看。