Clin Gastroenterology H: 饮料摄入与胃食管反流症状发生率之间的关联

2020-08-30 MedSci原创 MedSci原创

其实,胃内容物进入食道也就是我们常说的胃食管反流是一个正常的生理过程。大多数发作都很短暂,并不会引起症状,食道损伤或其他并发症。

        其实,胃内容物进入食道也就是我们常说的胃食管反流是一个正常的生理过程。大多数发作都很短暂,并不会引起症状,食道损伤或其他并发症。但是,有一类人如果发生了频繁的胃食管反流就会对食道造成肉眼可见的损害并引起一系列的症状。这些典型的症状如胃灼热和反流相关性症状。胃灼热最常见于餐后,通常为胸骨后区域的烧灼感。如果每周出现两天或两天以上的轻度症状,或者每周一天以上出现中度至重度症状,那么就需要进行干预了。那么有哪些诱因会导致这样的现象发生呢?其实我们日常喝的饮料就好诱发这样的现象出现。经常喝咖啡,茶和/或苏打水的患者都会发生胃食管反流(GER)的症状,本项研究就旨在这方面的研究。

 

         研究人员从前瞻性护士健康研究II队列中收集了来自48308名42-62岁的女性的数据,这些女性没有规律的GER症状,没有癌症,也没有服用质子泵抑制剂或H2受体激动剂。使用多元Cox比例风险模型评估饮料摄入量与GER症状风险之间的关联。

 

        在262641人年的随访期间,研究人员总共确定了7961名每周报告一次或多次GER症状的女性。经过多变量调整后,与每种饮料摄入量最低(0份/天)的女性相比,每种饮料摄入量最高(大于6份/天)的女性的危险比(HRs)为1.34(95%CI,1.13– 1.59; P<.0001),茶为1.26(95%CI,1.03-1.55; P趋势<.001),苏打水为1.29(95%CI,1.05-1.58; P趋势<.0001)。牛奶,水或果汁的消费与GER症状的风险之间没有关联。在替代分析中,每天用2份水代替2份咖啡,茶或苏打水可降低GERD症状的风险。

 

         本项研究证实摄入咖啡,茶或苏打水与GER症状的风险增加相关。相反,喝水,果汁或牛奶与GER症状无关。喝水代替咖啡,茶或苏打水可以降低GER症状的风险。

 

 原始出处:

Raaj S. Mehta. Et al. Association Between Beverage Intake and Incidence of Gastroesophageal Reflux Symptoms. Clin Gastroenterology H.2020.

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createdTime=Wed Dec 02 12:14:22 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826635, encodeId=a25d182663500, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Aug 11 00:14:22 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073093, encodeId=3a4d20e309382, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Dec 07 05:14:22 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065137, encodeId=e960206513e7e, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Oct 25 01:14:22 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948599, encodeId=55e01948599d5, content=<a href='/topic/show?id=87828339e7a' target=_blank style='color:#2F92EE;'>#胃食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83397, encryptionId=87828339e7a, topicName=胃食管)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Sat Oct 31 23:14:22 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260718, encodeId=ad8c1260e1885, content=<a href='/topic/show?id=2f71834056f' target=_blank style='color:#2F92EE;'>#胃食管反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83405, encryptionId=2f71834056f, topicName=胃食管反流)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Sep 01 07:14:22 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437570, encodeId=37cf143e570b3, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Sep 01 07:14:22 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505070, encodeId=7f1815050e00d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Sep 01 07:14:22 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571696, encodeId=e47015e1696bf, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Tue Sep 01 07:14:22 CST 2020, time=2020-09-01, status=1, ipAttribution=)]
    2020-12-07 hb2008ye
  5. 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  6. 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  7. 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  8. 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    2020-09-01 zhouqu_8
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    2020-09-01 feifers

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