J Gastroenterology: 质子泵抑制剂的使用对艰难梭菌感染风险的影响

2019-11-30 不详 MedSci原创

尽管对质子泵抑制剂(PPI)的使用与艰难梭菌感染(CDI)风险增加之间的关联进行了多项研究,但仍缺乏分析PPI对CDI风险影响的详细研究。本研究探究了PPI的剂量,持续时间和类型与CDI风险之间的关系。

背景
尽管对质子泵抑制剂(PPI)的使用与艰难梭菌感染(CDI)风险增加之间的关联进行了多项研究,但仍缺乏分析PPI对CDI风险影响的详细研究。本研究探究了PPI的剂量,持续时间和类型与CDI风险之间的关系。

方法
研究人员对入院的患者进行了单中心队列研究。暴露人群包括在研究期间至少接受过一次PPI处方的患者,并通过向未使用PPI的患者按照性别,年龄,住院时间和入院日期来准备对照队列。

结果
使用PPI可将CDI风险增加1.8倍[95%置信区间(CI)1.5-2.2]。埃索美拉唑(95%CI 1.4–2.2)使CDI风险增加了1.8倍,而泮托拉唑(95%CI 1.5–2.8)使CDI风险增加了2.0倍。与使用中等剂量的患者相比,使用高剂量的患者具有更高的风险[调整后的危险比(HR)为2.0 vs 1.3]。当PPI暴露期为6天或少于6天时,CDI的风险增加了4.2倍。

结论
本项研究表明,使用PPI会增加患CDI的风险,而CDI的风险是剂量依赖性的。因此,PPI仅应以适当剂量使用。

原始出处:

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    2020-05-19 许安
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    2020-02-26 jklm09
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