J Rheumatol:高血压风险升高与脊椎关节炎病程相关

2019-01-16 xiangting MedSci原创

ASAS-COMOSPA队列中,SpA病程与患HTN的几率较高相关,尤其是中轴型患者。

脊柱关节炎(SpA)与许多血管(CV)合并症有关。这项研究探讨了SpA病程与CV相关疾病延误诊断之间的关联。

使用来自COMOSPA研究的数据,在单因素和多因素logistic回归模型中评估了SpA病程与CV相关疾病之间的关联。每个模型分析1个CV相关因素作为因变量,"SpA病程"作为预测因子,并根据相关混杂因素进行调整。

3923名受试者的数据可用于分析(SpA中位病程为5.1年,四分位范围为1.3-11.8年)。主要的CV相关疾病是高血压(HTN; 22.4%)、缺血性心脏病(2.6%)、卒中(1.3%)和糖尿病(5.5%)。在单因素和多因素分析中,HTN与SpA病程相关,SpA病程每增加5年,OR为1.129(95%CI 1.072-1.189; p<0.001)。与HTN相关的其他因素是年龄、男性、当前的体重指数、曾经类固醇治疗和合成疾病改善性抗风湿药治疗,但不是非甾体类抗炎药(NSAID)。亚组分析中,仅中轴受累的SpA表型受试者HTN与病程的相关性最强(OR 1.202,95%CI 1.053-1.372),而不是仅外周受累的患者(OR 0.902,95%CI 0.760-1.070)。其他CV疾病与SpA病程无关。

ASAS-COMOSPA队列中,SpA病程与患HTN的几率较高相关,尤其是中轴型患者,但SpA病程与其他CV相关疾病无关。与HTN的相关性似乎与使用NSAID无关。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2045638, encodeId=7ce9204563814, content=<a href='/topic/show?id=2acc84568a2' target=_blank style='color:#2F92EE;'>#脊椎关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84568, encryptionId=2acc84568a2, topicName=脊椎关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Nov 08 01:13:00 CST 2019, time=2019-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265894, encodeId=289d1265894b1, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Fri Jan 18 05:13:00 CST 2019, time=2019-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630494, encodeId=2608163049453, content=<a href='/topic/show?id=dd238456e9f' target=_blank style='color:#2F92EE;'>#脊椎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84567, encryptionId=dd238456e9f, topicName=脊椎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f80c21536506, createdName=neizongke, createdTime=Fri Jan 18 05:13:00 CST 2019, time=2019-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358364, encodeId=b4403583648b, content=高血压的研究很重要啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53512532346, createdName=naturescience, createdTime=Wed Jan 16 19:07:51 CST 2019, time=2019-01-16, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2045638, encodeId=7ce9204563814, content=<a href='/topic/show?id=2acc84568a2' target=_blank style='color:#2F92EE;'>#脊椎关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84568, encryptionId=2acc84568a2, topicName=脊椎关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Nov 08 01:13:00 CST 2019, time=2019-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265894, encodeId=289d1265894b1, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Fri Jan 18 05:13:00 CST 2019, time=2019-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630494, encodeId=2608163049453, content=<a href='/topic/show?id=dd238456e9f' target=_blank style='color:#2F92EE;'>#脊椎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84567, encryptionId=dd238456e9f, topicName=脊椎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f80c21536506, createdName=neizongke, createdTime=Fri Jan 18 05:13:00 CST 2019, time=2019-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358364, encodeId=b4403583648b, content=高血压的研究很重要啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53512532346, createdName=naturescience, createdTime=Wed Jan 16 19:07:51 CST 2019, time=2019-01-16, status=1, ipAttribution=)]
    2019-01-18 lmm397
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    2019-01-18 neizongke
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    2019-01-16 naturescience

    高血压的研究很重要啊

    0

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