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Brit J Cancer：L1细胞粘附分子在胃癌中的临床意义和生物学作用

2019-11-23 xing.T MedSci原创

L1细胞粘附分子胃癌临床意义生物学作用
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由此可见，L1CAM可能是确定高GC复发风险患者的可行生物标志物。

L1细胞粘附分子（L1CAM）在恶性肿瘤中高表达，并可能在肿瘤进展中起关键作用。

近日，肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章，研究人员通过免疫组化分析了309例胃癌（GC）患者福尔马林固定、石蜡包埋的标本中L1CAM蛋白的表达。研究人员进行了倾向得分匹配（PSM）分析，以阐明L1CAM对GC患者的预后的影响。研究人员评估了另一组131名GC患者新鲜冰冻标本中的L1CAM基因表达，以确定其临床相关性。并在体内和体外实验中探究了L1CAM变化的影响。 

L1CAM主要在GC组织的肿瘤细胞中表达。L1CAM表达升高是GC患者总体生存和无病生存的独立预后因素，也是远处转移的独立危险因素。PSM分析显示，L1CAM高表达与不良预后显著相关。在独立的队列中使用新鲜的冷冻标本进行的L1CAM基因表达成功验证了所有这些发现。体外实验中，抑制L1CAM可显著抑制GC细胞的增殖、循环进程、侵袭、迁移和无神经碱抗性。此外，抑制L1CAM可显著抑制腹膜转移瘤的生长。

由此可见，L1CAM可能是确定高GC复发风险患者的可行生物标志物。 

原始出处：

Takashi Ichikawa,et al.Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer.British Journal of Cancer.2019.https://www.nature.com/articles/s41416-019-0646-8

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    2020-02-09 yinhl1978

    #L1细胞粘附分子#

    0

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    2020-01-25 cathymary

    #生物学作用#

    0

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    2019-11-25 12498c32m74暂无昵称

    #生物学#

    0

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    2019-11-23 1ddf0692m34(暂无匿称)

    学习了，谢谢分享

    0