BMJ:间隔期筛查与女性宫颈癌风险

2019-04-09 MedSci MedSci原创

研究认为,间隔期筛查可显著降低女性宫颈鳞癌和浸润性宫颈癌风险

近日研究人员探讨了宫颈细胞学筛查与宫颈鳞癌(ASC)和罕见组织学类型浸润性宫颈癌(RICC)的关系,并应用综合登记册数据,对ASC和RICC的肿瘤人乳头瘤病毒状况进行评估。

2002-11年间瑞典所有浸润性宫颈癌病例(临床和组织病理学检查后4254例确认病例)参与研究。鳞状细胞癌和腺癌338例,其中ASC 164例,RICC 174例(玻璃样细胞癌、透明细胞癌、小细胞癌、神经内分泌细胞癌、大细胞癌、未分化癌)。研究的主要终点为ASC和RIC与筛查的相关性。

研究发现,相比于未接受任何筛查人群,在推荐筛选间隔内进行两次筛选的妇女其ASC(RR=0.22)以及RICC(RR=0.34)风险显著降低,211名肿瘤患者中,148人(70%)HPV阳性,所有阳性标本均来自宫颈癌组织。相比于未接受筛查人群,HPV阳性(RR=0.28)或阴性(RR=0.27)人群继发性肿瘤风险降低程度相近。

研究认为,间隔期筛查可显著降低女性宫颈鳞癌和浸润性宫颈癌风险。

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    2019-09-26 sjq027
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    2019-04-13 gaoxiaoe
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    2019-04-11 一闲

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