美阿沙坦钾片药品说明书

2021-09-14 网络 网络

美阿沙坦钾,前体药物,适应症为成人原发性高血压。降低血压可减少致死性和非致死性心血管事件的风险,主要为减少卒中和心肌梗死事件风险。可单独应用或与其他抗高血压药物联合应用。美阿沙坦钾是由武田制药研发的血

美阿沙坦钾,前体药物,适应症为成人原发性高血压。降低血压可减少致死性和非致死性血管事件的风险,主要为减少卒中心肌梗死事件风险。可单独应用或与其他抗高血压药物联合应用。美阿沙坦钾是由武田制药研发的血管紧张素II受体拮抗剂(ARB)类药物。美阿沙坦钾是一种前体药物,在口服吸收后可迅速转化为活性成分阿齐沙坦。

药物成分

美阿沙坦钾
(5-甲基-2-氧代-1,3-二氧环戊烯-4-基)甲基2-乙氧基-1-{[2'-(5-氧-4,5-二氢-1,2,4-噁二唑-3-基)联苯-4-基]甲基}-1H-苯并咪唑-7-羧化物单钾盐
分子式:C30H23KN4O8
分子量:606.62
 

临床药理学:作用机制

美阿沙坦钾,是一种前体药物,在口服吸收后可迅速转化为活性成分阿齐沙坦,后者在多种组织中可通过选择性阻断血管紧张素II与AT1受体的结合而阻断血管紧张素II的作用。血管紧张素II是RAAS的主要升压物质,有收缩血管、刺激醛固酮合成和释放、心脏兴奋及肾脏对钠的再吸收等作用。美阿沙坦钾通过选择性阻断血管紧张素II与许多组织如血管平滑肌和肾上腺中AT1受体的结合来阻断血管紧张素II的血管收缩作用和醛固酮分泌作用。因此,其作用与血管紧张素II合成途径无关。美阿沙坦钾对AT1受体的亲和力比对AT2受体的亲和力高10,000倍以上。
在体外研究中,美阿沙坦钾显著抑制血管紧张素II与AT1受体的特异结合,而且与其他AT1受体拮抗剂(奥美沙坦、替米沙坦、缬沙坦和厄贝沙坦)相比,其抑制AT1受体的效果即使在洗脱后也是持续的。这些结果显示美阿沙坦钾是AT1受体的强效选择性拮抗剂,而与其他血管紧张素II受体拮抗剂(ARB)类药物相比,从AT1受体上解离下来更为缓慢。这些结合特性可能是美阿沙坦钾与其他ARB类药物相比,在体内具有明显且持久的降压作用的原因。
 

适用人群

美阿沙坦钾片在欧盟和美国被广泛应用于治疗成人原发性高血压
 

临床试验(降压疗效和安全性)

(1)White等人报道在1291名1期或2期高血压患者中进行的一项随机,双盲,安慰剂对照研究,研究目的是评估美阿沙坦钾治疗6周(40或80mg,每日一次)与最大批准剂量奥美沙坦酯(40mg每日一次)及缬沙坦(320mg每日一次)相比的降压疗效。研究主要疗效终点是24小时平均收缩压较基线的变化幅度。相比缬沙坦320mg和奥美沙坦酯40mg,美阿沙坦钾80mg都具有更好的降压疗效:美阿沙坦钾降低24小时平均收缩压达-14.3mmHg显著优于缬沙坦320mg(-10.0mmHg; P < 0.001)和奥美沙坦酯40mg(-11.7mmHg; P = 0.009)。与缬沙坦320mg相比,美阿沙坦钾40 mg更有效降低平均收缩压(平均差异为-3.2mmHg; p = 0.001]),且降压幅度不劣于奥美沙坦酯40mg(与奥美沙坦酯平均差异为-1.4mmHg)。在降低诊室收缩压方面,与奥美沙坦酯40mg(40mg美阿沙坦vs40mg奥美沙坦酯,p =0.018,80mg美阿沙坦vs40mg奥美沙坦酯,p=0.008)和缬沙坦320mg(40mg美阿沙坦vs320mg缬沙坦,p <0.001,80mg美阿沙坦vs320mg缬沙坦,p <0.001)相比,美阿沙坦钾40mg和80mg均更有效降低诊室收缩压。与安慰剂组、缬沙坦组、奥美沙坦组相比,美阿沙坦钾80mg治疗组中有58%(p = 0.05)的患者达到治疗反应(即SBP < 140mmHg或减少>20mmHg)。美阿沙坦钾的安全性和耐受性,与安慰剂和对照药物治疗组相比,并无差异。
(2)一项随机双盲安慰剂对照研究评估美阿沙坦钾有效性和安全性。所有患者随机接受美阿沙坦钾 20mg(n = 283)、40mg(n = 283)、80mg(n = 285),奥美沙坦酯 40mg治疗(n = 282),均每日一次或安慰剂(n = 142)治疗。主要终点为治疗6周后平均24小时动态收缩压(SBP)-较基线的变化。研究结束时,美阿沙坦钾80 mg的24小时平均收缩压降低幅度大于奥美沙坦酯40 mg,更多降低24小时平均收缩压2.1 mm Hg( P = 0.038),同时美阿沙坦钾40 mg的降幅不劣于奥美沙坦酯40毫克。美阿沙坦钾20mg、40mg和80mg的副作用与安慰剂无明显差异。
(3)一项随机,双盲,多中心研究中,使用24小时动态和诊室血压观察美阿沙坦钾在984名原发性高血压患者中的疗效,主要终点是治疗24周后24小时平均动态收缩压较基线的下降幅度。结果显示,与缬沙坦 320 mg(-11.3 mm Hg)相比,美阿沙坦钾 40 mg/80 mg均显著降低24小时平均动态收缩压(分别为-14.9 mm Hg和-15.3 mm Hg ,P 值均<0.001)。此外,与缬沙坦320mg(-11.6 mmHg)相比,美阿沙坦钾 40mg/80mg(分别-14.9 mmHg-16.9 mmHg)显著降低诊室收缩压(P值分别为P =0.015和P <0.001)。与此同时,与缬沙坦320mg相比,美阿沙坦钾40mg和80mg还可进一步降低24小时平均血压值和诊室舒张压,并具有显著统计学差异(所有比较均P≤0.001)。

专利情况

美阿沙坦钾拥有两项中国专利,均由Takeda Pharmaceutical Company Limited所有。
 
 
美阿沙坦钾片的主要优势

在沙坦类药物中,具有目前最高的血压达标率,在以往公认奥美沙坦为1片达标率最高的,而现在呢,一项研究发现,服用1片美阿沙坦治疗六周之后呢,诊室收缩压降幅可达17.6毫米汞柱,这比奥美沙坦还要大,比缬沙坦、氯沙坦、厄贝沙坦、替米沙坦,阿利沙坦,坎地沙坦等降压药降压幅度都要大,一粒40毫克的美阿沙坦比160毫克两粒的缬沙坦疗效是不相上下的,另外还有一组权威的数据显示,口服80毫克美阿沙坦可使24小时动态收缩压下降14.3毫米汞柱。

我们知道,对于一天的血压高低不稳定的这种患者,做24小时动态血压是很有必要的,而此项检查呢,又可以完美的检验美阿沙坦的降压效果。

除了它良好的降压效果和强度,我们更看重的是它属于沙坦药的服药的安全性与保护作用,那美阿沙坦作为沙坦药的“后起新秀”,还具有心血管和肾脏的保护作用,很多患者查心脏彩超,会发现自己得了左心房肥大,那么这个病理改变,其实就是高血压导致的,为了让心脏的结构更加合理。我们可以用一些可以改变心脏肥大的降压药,而美阿沙坦呢,有这一作用。

除此之外,美阿沙坦仍可以稳定动脉上的硬斑块,可使之不易脱落,这就一定程度上呢,避免了心梗脑梗的发生,另外,美阿沙坦,它还可以抗心肌的纤维化,很多人不知道心肌纤维化是什么意思,其实心肌纤维化就是心肌的钙化,就如同一块肉,逐渐的变成了石头一样,变硬了,不能再吃了,心肌纤维化一般是指心梗,发生心肌细胞大面积坏死,而又因为心肌细胞不可再生修复,所以,才会在坏死的区域发生纤维组织的增生,这就如同手上用刀划了一个大口子,落了一个大疤一样,那么这个瘢痕呢,就是我们所说的心肌纤维化,所以说,一旦有人得过心梗,或者是已存在了心肌纤维化,那他的寿命呢,必然会有所缩短,因为我们知道这种病理因素的存在呢,会直接影响他的心脏的功能,等待他的必定是心衰,一个人的心脏,如果不好,整个人的精气神儿便会没有了,所以说为了抗心肌纤维化,我们呢,还真需要认真的挑选降压药。

我们还知道沙坦药几乎都可以改善胰岛素抵抗,降低尿蛋白与保护肾脏,那我这里要着重说一说什么是胰岛素抵抗,胰岛素抵抗是很多血糖高朋友的痛点,说得更简单直白些呢,您可以这样理解,一个正常人体内的胰岛素呢,对糖类物质是很敏感的,少量的胰岛素就能够把血糖降下来,而出现胰岛素抵抗时呢,大量的胰岛素才能够对抗一定量的血糖,也就是说,糖对胰岛素不敏感了,那这就是所谓的胰岛素抵抗,不管什么原因导致的胰岛素抵抗,我们在服用美阿沙坦改善胰岛素抵抗的同时呢,也要从饮食上做出行动。

那么具体怎样改善胰岛素抵抗呢?我们只需要把糖或者是米饭、面条的量减少一点就可以了,因为只有吃进肚的能量少了,胰岛素分泌的才相对较少,那么省下来的胰岛素呢,就可以改善胰岛素抵抗,这也是大多数内分泌医生,为什么让糖尿病人控制高糖饮食的原因。

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    2021-10-04 1def6e10m76(暂无匿称)

    #高血压#美阿沙坦仍可以稳定动脉上的硬斑块,可使之不易脱落,这就一定程度上呢,避免了心梗脑梗的发生,另外,美阿沙坦,它还可以抗心肌的纤维化

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1057407, encodeId=b613105e40751, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>美阿沙坦仍可以稳定动脉上的硬斑块,可使之不易脱落,这就一定程度上呢,避免了心梗脑梗的发生,另外,美阿沙坦,它还可以抗心肌的纤维化, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInOuicIVN8Y32NO4Q53Zpd86ObmNp2WIotichCD0qQHaUBeHj7hgwQBCzX7ce4aEw5ZP8icQQfLH9Zw/132, createdBy=4ec21734756, createdName=1def6e10m76(暂无匿称), createdTime=Mon Oct 04 09:08:48 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507220, encodeId=a880150e220b2, content=<a href='/topic/show?id=18849189139' target=_blank style='color:#2F92EE;'>#说明书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91891, encryptionId=18849189139, topicName=说明书)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3da79876963, createdName=yangpeizhi, createdTime=Thu Sep 16 05:11:44 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628853, encodeId=5fd5162885371, content=<a href='/topic/show?id=57c38e486a2' target=_blank style='color:#2F92EE;'>#药品说明书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87486, encryptionId=57c38e486a2, topicName=药品说明书)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd8c21208991, createdName=fanweitanzhen, createdTime=Thu Sep 16 05:11:44 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051204, encodeId=7783105120470, content=我们的事业, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f59a1355471, createdName=xieqian_78, createdTime=Tue Sep 14 17:17:24 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051155, encodeId=dfe5105115542, content=对临床帮助非常大, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=谭桂峰, createdTime=Tue Sep 14 16:17:49 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051128, encodeId=c60210511283d, content=钻积分<a href='/topic/show?id=73c423e2572' target=_blank style='color:#2F92EE;'>#乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23725, encryptionId=73c423e2572, topicName=乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2fb85206775, createdName=1474f400m55暂无昵称, createdTime=Tue Sep 14 14:23:35 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051111, encodeId=505c1051111f8, content=<a href='/topic/show?id=bb46104168f9' target=_blank style='color:#2F92EE;'>#美阿沙坦钾片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104168, encryptionId=bb46104168f9, topicName=美阿沙坦钾片)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Sep 14 14:12:07 CST 2021, time=2021-09-14, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1057407, encodeId=b613105e40751, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>美阿沙坦仍可以稳定动脉上的硬斑块,可使之不易脱落,这就一定程度上呢,避免了心梗脑梗的发生,另外,美阿沙坦,它还可以抗心肌的纤维化, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInOuicIVN8Y32NO4Q53Zpd86ObmNp2WIotichCD0qQHaUBeHj7hgwQBCzX7ce4aEw5ZP8icQQfLH9Zw/132, createdBy=4ec21734756, createdName=1def6e10m76(暂无匿称), createdTime=Mon Oct 04 09:08:48 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507220, encodeId=a880150e220b2, content=<a href='/topic/show?id=18849189139' target=_blank style='color:#2F92EE;'>#说明书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91891, encryptionId=18849189139, topicName=说明书)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3da79876963, createdName=yangpeizhi, createdTime=Thu Sep 16 05:11:44 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628853, encodeId=5fd5162885371, content=<a href='/topic/show?id=57c38e486a2' target=_blank style='color:#2F92EE;'>#药品说明书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87486, encryptionId=57c38e486a2, topicName=药品说明书)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd8c21208991, createdName=fanweitanzhen, createdTime=Thu Sep 16 05:11:44 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051204, encodeId=7783105120470, content=我们的事业, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f59a1355471, createdName=xieqian_78, createdTime=Tue Sep 14 17:17:24 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051155, encodeId=dfe5105115542, content=对临床帮助非常大, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=谭桂峰, createdTime=Tue Sep 14 16:17:49 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051128, encodeId=c60210511283d, content=钻积分<a href='/topic/show?id=73c423e2572' target=_blank style='color:#2F92EE;'>#乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23725, encryptionId=73c423e2572, topicName=乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2fb85206775, createdName=1474f400m55暂无昵称, createdTime=Tue Sep 14 14:23:35 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051111, encodeId=505c1051111f8, content=<a href='/topic/show?id=bb46104168f9' target=_blank style='color:#2F92EE;'>#美阿沙坦钾片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104168, encryptionId=bb46104168f9, topicName=美阿沙坦钾片)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Sep 14 14:12:07 CST 2021, time=2021-09-14, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1057407, encodeId=b613105e40751, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>美阿沙坦仍可以稳定动脉上的硬斑块,可使之不易脱落,这就一定程度上呢,避免了心梗脑梗的发生,另外,美阿沙坦,它还可以抗心肌的纤维化, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInOuicIVN8Y32NO4Q53Zpd86ObmNp2WIotichCD0qQHaUBeHj7hgwQBCzX7ce4aEw5ZP8icQQfLH9Zw/132, createdBy=4ec21734756, createdName=1def6e10m76(暂无匿称), createdTime=Mon Oct 04 09:08:48 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507220, encodeId=a880150e220b2, content=<a href='/topic/show?id=18849189139' target=_blank style='color:#2F92EE;'>#说明书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91891, encryptionId=18849189139, topicName=说明书)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3da79876963, createdName=yangpeizhi, createdTime=Thu Sep 16 05:11:44 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628853, encodeId=5fd5162885371, content=<a href='/topic/show?id=57c38e486a2' target=_blank style='color:#2F92EE;'>#药品说明书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87486, encryptionId=57c38e486a2, topicName=药品说明书)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd8c21208991, createdName=fanweitanzhen, createdTime=Thu Sep 16 05:11:44 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051204, encodeId=7783105120470, content=我们的事业, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f59a1355471, createdName=xieqian_78, createdTime=Tue Sep 14 17:17:24 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051155, encodeId=dfe5105115542, content=对临床帮助非常大, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=谭桂峰, createdTime=Tue Sep 14 16:17:49 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051128, encodeId=c60210511283d, content=钻积分<a href='/topic/show?id=73c423e2572' target=_blank style='color:#2F92EE;'>#乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23725, encryptionId=73c423e2572, topicName=乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2fb85206775, createdName=1474f400m55暂无昵称, createdTime=Tue Sep 14 14:23:35 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051111, encodeId=505c1051111f8, content=<a href='/topic/show?id=bb46104168f9' target=_blank style='color:#2F92EE;'>#美阿沙坦钾片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104168, encryptionId=bb46104168f9, topicName=美阿沙坦钾片)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Sep 14 14:12:07 CST 2021, time=2021-09-14, status=1, ipAttribution=)]
    2021-09-14 xieqian_78

    我们的事业

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1057407, encodeId=b613105e40751, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>美阿沙坦仍可以稳定动脉上的硬斑块,可使之不易脱落,这就一定程度上呢,避免了心梗脑梗的发生,另外,美阿沙坦,它还可以抗心肌的纤维化, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInOuicIVN8Y32NO4Q53Zpd86ObmNp2WIotichCD0qQHaUBeHj7hgwQBCzX7ce4aEw5ZP8icQQfLH9Zw/132, createdBy=4ec21734756, createdName=1def6e10m76(暂无匿称), createdTime=Mon Oct 04 09:08:48 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507220, encodeId=a880150e220b2, content=<a href='/topic/show?id=18849189139' target=_blank style='color:#2F92EE;'>#说明书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91891, encryptionId=18849189139, topicName=说明书)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3da79876963, createdName=yangpeizhi, createdTime=Thu Sep 16 05:11:44 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628853, encodeId=5fd5162885371, content=<a href='/topic/show?id=57c38e486a2' target=_blank style='color:#2F92EE;'>#药品说明书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87486, encryptionId=57c38e486a2, topicName=药品说明书)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd8c21208991, createdName=fanweitanzhen, createdTime=Thu Sep 16 05:11:44 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051204, encodeId=7783105120470, content=我们的事业, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f59a1355471, createdName=xieqian_78, createdTime=Tue Sep 14 17:17:24 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051155, encodeId=dfe5105115542, content=对临床帮助非常大, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=谭桂峰, createdTime=Tue Sep 14 16:17:49 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051128, encodeId=c60210511283d, content=钻积分<a href='/topic/show?id=73c423e2572' target=_blank style='color:#2F92EE;'>#乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23725, encryptionId=73c423e2572, topicName=乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2fb85206775, createdName=1474f400m55暂无昵称, createdTime=Tue Sep 14 14:23:35 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051111, encodeId=505c1051111f8, content=<a href='/topic/show?id=bb46104168f9' target=_blank style='color:#2F92EE;'>#美阿沙坦钾片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104168, encryptionId=bb46104168f9, topicName=美阿沙坦钾片)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Sep 14 14:12:07 CST 2021, time=2021-09-14, status=1, ipAttribution=)]
    2021-09-14 谭桂峰

    对临床帮助非常大

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1057407, encodeId=b613105e40751, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>美阿沙坦仍可以稳定动脉上的硬斑块,可使之不易脱落,这就一定程度上呢,避免了心梗脑梗的发生,另外,美阿沙坦,它还可以抗心肌的纤维化, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInOuicIVN8Y32NO4Q53Zpd86ObmNp2WIotichCD0qQHaUBeHj7hgwQBCzX7ce4aEw5ZP8icQQfLH9Zw/132, createdBy=4ec21734756, createdName=1def6e10m76(暂无匿称), createdTime=Mon Oct 04 09:08:48 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507220, encodeId=a880150e220b2, content=<a href='/topic/show?id=18849189139' target=_blank style='color:#2F92EE;'>#说明书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91891, encryptionId=18849189139, topicName=说明书)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3da79876963, createdName=yangpeizhi, createdTime=Thu Sep 16 05:11:44 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628853, encodeId=5fd5162885371, content=<a href='/topic/show?id=57c38e486a2' target=_blank style='color:#2F92EE;'>#药品说明书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87486, encryptionId=57c38e486a2, topicName=药品说明书)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd8c21208991, createdName=fanweitanzhen, createdTime=Thu Sep 16 05:11:44 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051204, encodeId=7783105120470, content=我们的事业, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f59a1355471, createdName=xieqian_78, createdTime=Tue Sep 14 17:17:24 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051155, encodeId=dfe5105115542, content=对临床帮助非常大, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=谭桂峰, createdTime=Tue Sep 14 16:17:49 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051128, encodeId=c60210511283d, content=钻积分<a href='/topic/show?id=73c423e2572' target=_blank style='color:#2F92EE;'>#乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23725, encryptionId=73c423e2572, topicName=乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2fb85206775, createdName=1474f400m55暂无昵称, createdTime=Tue Sep 14 14:23:35 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051111, encodeId=505c1051111f8, content=<a href='/topic/show?id=bb46104168f9' target=_blank style='color:#2F92EE;'>#美阿沙坦钾片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104168, encryptionId=bb46104168f9, topicName=美阿沙坦钾片)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Sep 14 14:12:07 CST 2021, time=2021-09-14, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1057407, encodeId=b613105e40751, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>美阿沙坦仍可以稳定动脉上的硬斑块,可使之不易脱落,这就一定程度上呢,避免了心梗脑梗的发生,另外,美阿沙坦,它还可以抗心肌的纤维化, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInOuicIVN8Y32NO4Q53Zpd86ObmNp2WIotichCD0qQHaUBeHj7hgwQBCzX7ce4aEw5ZP8icQQfLH9Zw/132, createdBy=4ec21734756, createdName=1def6e10m76(暂无匿称), createdTime=Mon Oct 04 09:08:48 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507220, encodeId=a880150e220b2, content=<a href='/topic/show?id=18849189139' target=_blank style='color:#2F92EE;'>#说明书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91891, encryptionId=18849189139, topicName=说明书)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3da79876963, createdName=yangpeizhi, createdTime=Thu Sep 16 05:11:44 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628853, encodeId=5fd5162885371, content=<a href='/topic/show?id=57c38e486a2' target=_blank style='color:#2F92EE;'>#药品说明书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87486, encryptionId=57c38e486a2, topicName=药品说明书)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd8c21208991, createdName=fanweitanzhen, createdTime=Thu Sep 16 05:11:44 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051204, encodeId=7783105120470, content=我们的事业, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f59a1355471, createdName=xieqian_78, createdTime=Tue Sep 14 17:17:24 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051155, encodeId=dfe5105115542, content=对临床帮助非常大, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=谭桂峰, createdTime=Tue Sep 14 16:17:49 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051128, encodeId=c60210511283d, content=钻积分<a href='/topic/show?id=73c423e2572' target=_blank style='color:#2F92EE;'>#乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23725, encryptionId=73c423e2572, topicName=乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2fb85206775, createdName=1474f400m55暂无昵称, createdTime=Tue Sep 14 14:23:35 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051111, encodeId=505c1051111f8, content=<a href='/topic/show?id=bb46104168f9' target=_blank style='color:#2F92EE;'>#美阿沙坦钾片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104168, encryptionId=bb46104168f9, topicName=美阿沙坦钾片)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Sep 14 14:12:07 CST 2021, time=2021-09-14, status=1, ipAttribution=)]

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