J Hypertens:血糖恶化与主动脉硬化程度以及中心动脉压之间有何关系?

2017-05-20 xing.T MedSci原创

由此可见,糖代谢紊乱与主动脉硬化程度相关。然而,7.8年期间血糖恶化并不影响主动脉硬化或中心血压,独立于其他心血管代谢危险因素。

近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,在糖尿病筛查中,研究人员评估了不同糖尿病风险人群的中央血流动力学,并分析了糖化血红蛋白(HbA1c)水平和HbA1c变化值对中心血流动力学的影响。

在丹麦以人群为基础的糖尿病逐步筛查方案中,包括了糖尿病风险评分(DRS)问卷和葡萄糖测量根据个人糖尿病风险水平的增加确定了七组。经过7.8年的随访,2048人接受颈股动脉脉搏波速度(aPWV)检查评估了主动脉硬化程度并且评估了中心血压。研究人员比较了随访后不同糖尿病风险组间中心血流动力学的差异,并在随访调整相关的混杂因素后,分析了筛查时HbA1c水平与HbA1c变化值对中心血流动力学的影响。

在筛查时,参与者中位年龄为59岁,中位HbA1c水平为5.7%。在随访中,中位aPWV为8米/秒,平均中心收缩压为123.5mmHg。在高DRS的个人中,糖耐量异常患者的aPWV、中心收缩压、舒张压和脉压较高,相比于正常糖耐量个人。筛查时HbA1c每升高1%点,aPWV增加0.23米/秒(95%可信区间为0-0.46),而中心舒张压降低1.35mmHg(95%可信区间为0.19-2.51),而HbA1c的变化值并不与任何中心血流动力学指标相关。

由此可见,糖代谢紊乱与主动脉硬化程度相关。然而,7.8年期间血糖恶化并不影响主动脉硬化或中心血压,独立于其他心血管代谢危险因素。

原始出处:

Johansen, Nanna B,et al. Associations between glycaemic deterioration and aortic stiffness and central blood pressure: the ADDITION-PRO Study.Journal of Hypertension. 2017. http://journals.lww.com/jhypertension/Abstract/publishahead/Associations_between_glycaemic_deterioration_and.97716.aspx

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    2017-10-01 shuangle
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channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Tue May 23 09:08:14 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415135, encodeId=8ee714151352b, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 22 13:23:00 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201148, encodeId=9a732011485b, content=文章真好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon May 22 08:44:45 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-12-29 feather89
  5. 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content=文章真好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon May 22 08:44:45 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-06-03 jyzxjiangqin

    血糖恶化与主动脉硬化。

    0

  6. 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channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Tue May 23 09:08:14 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415135, encodeId=8ee714151352b, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 22 13:23:00 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201148, encodeId=9a732011485b, content=文章真好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon May 22 08:44:45 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-27 lou.minghong

    学习

    0

  7. 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content=文章真好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon May 22 08:44:45 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-27 惠映实验室

    独立因素研究,耗时长。

    0

  8. 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content=文章真好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon May 22 08:44:45 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-23 flysky120

    学习一下知识

    0

  9. 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    2017-05-22 1e10c84am36(暂无匿称)

    文章真好,拜读了

    0

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摄入新鲜水果有它的好处,相对不新鲜的水果来说,新鲜水果的糖分低,维生素 C、果胶含量多,对代谢,包括心血管疾病等都有好的作用。

姜黄素真的有如此神?让肿瘤萎缩?减少机体疼痛并且杀菌?

2017年4月29日 讯 /生物谷BIOON/ --姜黄素(turmeric)是一种黄色的香料,其广泛用于印度和东南亚的菜肴美食之中,姜黄素是从植物姜黄根中提取出来的,其还是食品工业加工中的一种天然色素。有研究报告,姜黄素是一种能够保护机体抵御活性分子损伤的氧化剂,机体中代谢所产生的活性氧分子能够引发细胞损伤。 同时有研究人员姜黄素还具有抗炎性、抗菌以及抗癌的特性,其还能够促进机体中危

Cell Metab:“运动药丸”真能代替运动吗?

发表在5月2日《Cell Metabolism》上的一项新研究,或许给无法运动且理由太多的人士带来了福音:你不需要在健身房挥汗如雨,只需吃个药丸就能获得体育训练带来的益处。这种“运动药丸”对于喜欢躺在沙发里看电视的人、长途上车司机以及压力山大的上班一族是个好消息。研究人员相信,这种药物能够改变无数由于肥胖或严重身体残疾而无法运动的人的生活。科学家们发现,一种实验药物能够使小鼠在跑步机上跑270分钟

Sci Rep:血糖升高时胶质瘤发生反而下降!

最新一项研究揭示了血糖和脑癌之间惊人的关系,这也有助于解析其它种类的癌症的发展。来自俄亥俄州立大学的研究人员发现虽然在糖尿病患者中癌症出现的几率更高,但是对于胶质瘤这种脑肿瘤疾病来说,出现在血糖升高和糖尿病患者中较为少见,这是为什么呢?这篇最新发表在Scientific Reports杂志上的文章是建立在之前俄亥俄州立大学Judith Schwartzbaum研究组得到的研究结果(高血糖似乎降低了