Circulation:用遗传突变预测降压药的疗效和副作用

2019-07-28 MedSci MedSci原创

可以通过靶蛋白基因的自然变异来研究药物作用。本研究旨在利用这一方法研究最常用的抗高血压药物的潜在副作用和再利用潜力。抗高血压药物类作用的遗传代理定义为在全基因组意义上,与收缩压相关的相应靶基因变异。同时评估药物对冠心病和中风风险的影响。结果:确认了血管紧张素转换酶抑制剂、β受体阻断剂、钙通道阻滞剂(CCBs)适宜的遗传代理。UK BioBank的一个全基因组关联分析发现CCB标准遗传风险评分与憩室

可以通过靶蛋白基因的自然变异来研究药物作用。本研究旨在利用这一方法研究最常用的抗高血压药物的潜在副作用和再利用潜力。

高血压药物类作用的遗传代理定义为在全基因组意义上,与收缩压相关的相应靶基因变异。同时评估药物对冠心病和中风风险的影响。

结果:确认了血管紧张素转换酶抑制剂、β受体阻断剂、钙通道阻滞剂(CCBs)适宜的遗传代理。UK BioBank的一个全基因组关联分析发现CCB标准遗传风险评分与憩室病风险增加相关(OR 1.02/标准差增加,95% CI 1.1-1.04),该结果与BioVU评估的一致(OR 1.01,95% CI 1.00–1.02)。药物使用的回归曲线分析显示这种相关性是非二氢吡啶CCBs所特异性的(以噻嗪类利尿剂为对照,危险比1.49,95% CI,1.04-2.14),而二氢吡啶CCBs则无这种相关性(1.04,95% CI 0.83-1.32)。

基因变异可用于探索抗高血压药物的疗效和副作用。现已确定的非二氢吡啶CCBs对憩室病风险的潜在影响可能具有一定临床意义,值得进一步研究。

原始出处:

Dipender Gill,et al.Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects.https://doi.org/10.1161/CIRCULATIONAHA.118.038814Circulation. 2019;140:270–279

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    2019-07-29 phoebeyan520

    学习了

    0

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    2019-07-29 yjs木玉

    好好好好好好

    0

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    2019-07-29 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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    2019-07-29 飛歌

    学习了很有用不错

    0

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