JAHA:左心室射血分数、室壁运动异常与未确定来源栓塞性卒中的关系

2019-05-06 xing.T 网络

由此可见,在整个队列中,LVEF或LV室壁运动异常与ESUS之间不存在关联;然而,在排除任何有同侧颈动脉粥样硬化证据的ESUS患者后,较低的LVEF似乎与ESUS有关。

左心室射血分数(LVEF)或左室壁运动异常与未确定来源(ESUS)的栓塞性卒中之间是否存在关联尚未明确。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员对2011年至2016年入选CAESAR(康奈尔急性卒中学术登记处)的急性缺血性卒中患者进行了一项回顾性横断面研究。

研究人员将这项研究限制在ESUS患者和小动脉和大动脉缺血性卒中对照者中。LVEF必须高于35%才能被视为ESUS。在二级分析中,研究人员排除了有任何同侧颈动脉粥样硬化证据的ESUS患者。多重Logistic回归用于评估LVEF或LV壁运动异常是否与ESUS相关。研究人员在另一家三级医疗中心进行了验证性研究。

研究人员确定了885名患有ESUS(n=503)或小动脉或大动脉卒中(n=382)的患者。在整个队列中,LVEF与ESUS无关(LVEF每5%递减的比值比为1.0; 95%CI为1.0-1.1),LV壁运动异常与ESUS无关(比值比为0.9; 95%CI为0.5-1.6)。验证性研究结果相同。在次要分析中,排除任何有同侧颈动脉粥样硬化证据的ESUS患者,LVEF和ESUS之间存在关联(LVEF中每5%减少的比值比为1.2; 95%CI为1.0-1.5; P=0.04)。

由此可见,在整个队列中,LVEF或LV室壁运动异常与ESUS之间不存在关联;然而,在排除任何有同侧颈动脉粥样硬化证据的ESUS患者后,较低的LVEF似乎与ESUS有关。 

原始出处:

Shobana Ramasamy.et al.Association Between Left Ventricular Ejection Fraction, Wall Motion Abnormality, and Embolic Stroke of Undetermined Source.JAHA.2019.https://www.ahajournals.org/doi/full/10.1161/JAHA.118.011593

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    2019-06-28 gous
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    2019-05-08 zhaojie88
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    2019-05-06 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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