A&R:磁共振成像评估软骨下囊肿和突发性膝痛和膝骨关节炎:来自多中心骨关节炎研究的数据

2022-01-22 MedSci原创 MedSci原创

软骨下囊肿可能是放射学膝关节骨关节炎的次要现象,而不是主要触发因素,并且可能预测患有现有疾病的膝关节的症状。

     目的:检查通过磁共振成像 (MRI) 测量的膝关节软骨下囊肿是否与偶发膝关节骨关节炎 (OA) 的结果相关。

     方法:研究者使用来自多中心骨关节炎研究的纵向数据,这是一个以社区为基础的具有膝关节OA危险因素的受试者队列。对没有膝关节手术史和/或炎症性关节炎(即类风湿性关节炎和痛风)的参与者进行了84个月的随访,结果如下:1)影像学膝关节OAKellgren/Lawrence分级≥2),2)症状性影像学膝关节OAX线膝关节OA和频繁的膝关节疼痛),以及 3) 频繁的膝关节疼痛(有或没有X线膝关节OA)。在一部分参与者中,对1个膝关节的基线MRI软骨下囊肿进行评分。多元逻辑回归,调整参与者特征和其他基线膝关节MRI结果,用于评估软骨下囊肿是否可预测事件结果。

     结果:在84个月内有资格进行结果分析的膝关节参与者中,无基线影像学膝关节OA的人群中22.8%的膝关节发生放射影像学膝关节OA,基线无症状性影像学膝关节OA的人群中17.0%发生有症状的影像学膝关节OA,以及28.8%的膝关节无基线放射学膝关节OA 43.7%的膝关节有基线放射学膝关节OA的人群经常发生疼痛。校正年龄、性别和体重指数后,软骨下囊肿的存在与影像学膝关节OA的发生率无关,但与发生症状性膝关节 OA的几率增加相关(比值比1.92 [95%置信区间 1.16-3.19] ) 并且在基线时有放射学膝关节OA的患者中发生频繁膝关节疼痛的几率增加(比值比2.11 [95% 置信区间 0.87-5.12]。根据研究访问后约1个月内频繁出现膝关节疼痛的一致报告,观察到结果与结果之间存在更强和更显著的关联。

      总结:软骨下囊肿可能是放射学膝关节OA的次要现象,而不是主要触发因素,并且可能预测患有现有疾病的膝关节的症状。

 

出处:

Perry, T.A., O'Neill, T.W., Tolstykh, I., Lynch, J., Felson, D.T., Arden, N.K. and Nevitt, M.C. (2022), Magnetic Resonance Imaging–Assessed Subchondral Cysts and Incident Knee Pain and Knee Osteoarthritis: Data From the Multicenter Osteoarthritis Study. Arthritis Rheumatol, 74: 60-69. https://doi.org/10.1002/art.41917

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  4. [GetPortalCommentsPageByObjectIdResponse(id=2026724, encodeId=11152026e24c1, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Mon Oct 17 21:04:38 CST 2022, time=2022-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904113, encodeId=b94a1904113a3, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341763, encodeId=2a441341e6319, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Mon Jan 24 04:04:38 CST 2022, time=2022-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187523, encodeId=2061118e52342, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, 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  5. [GetPortalCommentsPageByObjectIdResponse(id=2026724, encodeId=11152026e24c1, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Mon Oct 17 21:04:38 CST 2022, time=2022-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904113, encodeId=b94a1904113a3, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341763, encodeId=2a441341e6319, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Mon Jan 24 04:04:38 CST 2022, time=2022-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187523, encodeId=2061118e52342, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sun Jan 23 19:50:56 CST 2022, time=2022-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187359, encodeId=6e1e118e359f5, content=AASIS是由一个团队开发的专业工具,其目标是, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Sun Jan 23 07:39:27 CST 2022, time=2022-01-23, status=1, ipAttribution=)]
    2022-01-24 lmm397
  6. 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  7. 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  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341763, encodeId=2a441341e6319, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Mon Jan 24 04:04:38 CST 2022, time=2022-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187523, encodeId=2061118e52342, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, 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  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341763, encodeId=2a441341e6319, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Mon Jan 24 04:04:38 CST 2022, time=2022-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187523, encodeId=2061118e52342, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sun Jan 23 19:50:56 CST 2022, time=2022-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187359, encodeId=6e1e118e359f5, content=AASIS是由一个团队开发的专业工具,其目标是, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Sun Jan 23 07:39:27 CST 2022, time=2022-01-23, status=1, ipAttribution=)]
    2022-01-23 屋顶瞄爱赏月

    学习了

    0

  10. 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    AASIS是由一个团队开发的专业工具,其目标是

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